CAS: 286930-03-8; (R)-2-(3-(Diisopropylamino)-1-Phenylpropyl)-4-(Hydroxymethyl)Phenyl Isobutyrate Fumarate

上下游产品

fesoterodine (2E)-but-2-enedioic acid isobutyryl chloride (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

📜(R)-5-羟甲基托特罗定置于三乙胺体系中,用 二氯甲烷,环己烷,丁酮 用作溶剂,化学反应 21.92H,反应生成富马酸非索罗定
参考文献: Short Synthesis Of Tolterodine,Intermediates And Metabolites[fr] Synthèse Courte De Toltéropine,Intermédiaires Et Métabolites
标题: Short Synthesis Of Tolterodine,Intermediates And Metabolites[fr] Synthèse Courte De Toltéropine,Intermédiaires Et Métabolites
摘要:描述了一种用于制备中间体的过程,这些中间体可用于制备尿失禁治疗药物,特别是用于2-(3-(二异丙基氨基)-1-苯基丙基)-4-(羟甲基)苯酚及其前药的制备.

专利信息

专利号:US-7985873-B2
优先权日:2006-06-09
标题:Synthesis of phenolic esters of hydroxymethyl phenols
发明人：ENNIS SETH C; DREWS ROLAND; MEESE CLAUS
权利人:UCB PHARMA GMBH
摘要:The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C 1 -C 6 alkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine.

专利号:US-9751828-B2
优先权日:2014-07-30
标题:Antimuscarinic compound having a low content of impurities
发明人：ALLEGRINI PIETRO; ATTOLINO EMANUELE; GRAZIOSI RENZO
权利人:DIPHARMA FRANCIS SRL
摘要:Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.

专利号:WO-2014012832-A1
优先权日:2012-07-16
标 题:Process for the preparation of 2-(3-n,n-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol and its derivatives
发明人：PICCOLO ORESTE; GIANNINI ELIOS; BIGINI LAURA; GIANOLLI EDOARDO; VIGO DANIELE
权利人:CAMBREX PROFARMACO MILANO S R L
摘要:The invention concerns a process for the preparation of 2-(3-N,N- diisopropylamino-l-phenylpropyl)-4-hydroxymethyl-phenol and its derivatives, particularly the corresponding (R) 4-trityloxymethyl derivative, useful as intermediate form in the synthesis of Fesoterodine and its salts, in particular for the preparation of Fesoterodine fumarate salt.

专利号:ES-2350611-T3
优先权日:2006-06-09
标 题 :SYNTHESIS OF PHENOLIC ESTERS OF HYDROXYMETHYLPHENOLS.

专利号:WO-2011110556-A1
优先权日:2010-03-09
标 题:Short synthesis of tolterodine, intermediates and metabolites

专利号:CA-2648333-C
优先权日:2006-06-09
标 题:Synthesis of phenolic esters of hydroxymethyl phenols