专利号:US-7241399-B2 优先权日:2000-09-08 标题 :Synthesis of nanoparticles 发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKI KARSTEN; WELLER HORST; MEYSSAMY HEIKE; IBARRA FERNANDO 权利人:CT ANGEWANDTE NANOTECH CAN 摘要:Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.
专利号:US-2012177593-A1 优先权日:2009-07-20 标 题 :Synthesis of dendrimer conjugates 发明人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH 权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN 摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
专利号:WO-9902264-A1 优先权日:1997-07-11 标题:Membrane and method for synthesis of hydrogen peroxide 发明人:MCINTYRE JAMES A; SANDERS EDGAR S JR; MAHONEY ROBERT D; WEBB STEVEN P; MURCHISON CRAIG B; HAYES DAVID A 权利人:DOW CHEMICAL CO; MCINTYRE JAMES A; SANDERS EDGAR S JR; MAHONEY ROBERT D; WEBB STEVEN P; MURCHISON CRAIG B; HAYES DAVID A 摘要:This invention is a membrane which is useful for the synthesis of hydrogen peroxide from hydrogen and oxygen. The membrane has a hydrogen contact side and an oxygen contact side and comprises a porous hydrophobic catalyst layer facing the oxygen contact side and a gas flux control layer facing the hydrogen contact side. The gas flux control layer is positioned between the hydrogen contact side and the porous hydrophobic catalyst layer such that the flux of hydrogen may be controllably delivered to the porous hydrophobic catalyst layer. The membrane and method may be used to controllably synthesize hydrogen peroxide directly from hydrogen and oxygen without the use of organic solvents or complex equipment for ionic and electrical transport.
专利号:US-9777027-B2 优先权日:2013-10-25 标 题 :Method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid 发明人:NOTTÉ PATRICK PIERRE; COGELS SAMUEL 权利人:STRAITMARK HOLDING AG 摘要:The present invention is related to a method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid or its salt which includes the steps of reacting tetraphosphorus hexaoxide and acetic acid under controlled reaction conditions; hydrolyzing the formed ethane-1-hydroxy-1,1-diphosphonic acid condensates to form ethane-1-hydroxy-1,1-diphosphonic acid; further processing the ethane-1-hydroxy-1,1-diphosphonic acid solution. The process according to the method of the present invention is highly controllable and further is characterized by a high selectivity.
专利号:US-7202226-B2 优先权日:2000-10-23 标 题 :Augmentation of wound healing by elF-4E mRNA and EGF mRNA 发明人:MURRAY MARY THERESA; DULCHAVSKY SCOTT ALEXANDER 权利人:DETROIT R & D 摘要:There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.
专利号:WO-2017100796-A1 优先权日:2015-12-11 标 题 :Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers 发明人:WONG CHI-HUEY; HSU TSUI-LING; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI 权利人:SINACA ACAD; WONG CHI-HUEY; HSU TSUI-LING 摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.
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