📜1,5-二溴戊烷,乙炔钠置于氨体系中,化学反应生成1,8-壬二炔 参考文献:Lespieau; Journaud,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1929,Vol. 188,P. 1410 标题:Lespieau; Journaud,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1929,Vol. 188,P. 1410
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-9006345-B2 优先权日:2011-03-25 标题 :Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials 发明人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J 权利人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J; UNIV COLUMBIA 摘要:In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.
专利号:US-3578724-A 优先权日:1968-03-04 标 题:Migration and isomerization of acetylenes 发明人:HUBERT ANDRE JULES 权利人:UNION CARBIDE CORP 摘要:PROCESS FOR THE MIGRATION OF ACETYLENIC BONDS AND A PROCESS FOR THE ISOMERIZATION OF HYDROCARBONS CONTAINING ACETYLENIC BONDS TO HYDROCARBONS CONTAINING CONJUGATED UNSATURATION, BY CONTACTING A COMPOUND CONTAINING ONE OR TWO ACETYLENIC BONDS WITH POTASSIUM AMIDE ON ALUMINA. THE UNSATURATED COMPOUNDS PRODUCED BY THE PROCESS OF THE INVENTION ARE USEFUL AS ULTRAVIOLET LIGHT ABSORBERS, AS CROSS-LINKING AGENTS FOR POLYOLEFINIC ELASTOMERS, AND AS INTERMEDIATES IN THE SYNTHESIS OF NEW COMPOUNDS.
专利号:US-2003082830-A1 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-5977394-A 优先权日:1998-03-13 标题:Silyl thioalkene compound and method for the preparation thereof 发明人:HAN LI-BIAO; TANAKA MASATO 权利人:AGENCY IND SCIENCE TECHN 摘要:Disclosed is a silyl thioalkene compound, as a class of organosilicon compounds, represented by the general formula n n R(--CSArâ•?CHSiX.sub.3).sub.n, n n in which the subscript n is 1 or 2, R is, when n is 1, a hydrogen atom or unsubstituted or substituted monovalent hydrocarbon group or, when n is 2, a divalent hydrocarbon group, Ar is an unsubstituted or nucleus-substituted aromatic monovalent aromatic hydrocarbon group and X is a halogen atom, a monovalent hydrocarbon group or hydrocarbyloxy group, having usefulness as an intermediate in the synthesis of various precision organic chemicals. The compound, of which X is a halogen atom X 1 , can be prepared, for example, by the reaction of an alkyne compound of the general formula n n R(--C.tbd.CH).sub.n, n n with a silyl sulfide compound of the general formula n n ArS--SiX.sup.1.sub.3, n n in the presence of a platinum complex catalyst. The compound, of which X is a monovalent hydrocarbon group or a hydrocarbyloxy group, can be derived from the above obtained halogen-containing compoud.
专利号:US-10183955-B2 优先权日:2015-07-21 标题:Molecules for isolation of polyribosomes, ribosomes, uses and kits thereof 发明人:CLAMER MASSIMILIANO; VIERO GABRIELLA; GUELLA GRAZIANO; QUATTRONE ALESSANDRO 权利人:IMMAGINA BIOTECHNOLOGY S R L 摘要:Molecules of general Formula (I): able to bind to native polyribosomes engaged in active protein synthesis. The disclosure relates also to the use of the molecules of general Formula (I) for isolating at least one active ribosome from a biological sample, and for ribosome profiling, as well as kits for isolating at least one active ribosome from a biological sample.
参考标题:Enantioselective Synthesis Of Axially Chiral Biaryls By Diels-Alder/retro-Diels-Alder Reaction Of 2-Pyrones With Alkynes 作者:Meng-Meng Xu,Xin-Yu You,Yu-Zhen Zhang,Yang Lu,Kui Tan,Limin Yang,Quan Cai |发布日期:2021.6.23 摘要:The Enantioselective Synthesis Of Axially Chiral Biaryls By A Copper-Catalyzed Diels-Alder/retro-Diels-Alder Reaction Of 2-Pyrones With Alkynes Is Reported Herein. Using Electron-Deficient 2-Pyrones And Electron-Rich 1-Naphthyl Acetylenes As The Reaction Partners, A Broad Range Of Axially Chiral Biaryl Esters Are Obtained In Excellent Yields (Up To 97% Yield) And Enantioselectivities (Up To >99% Ee)
合成参考文献
摘要:Agrahari, A. K.; Mishra, A.; Tiwari, V. K., Science of Synthesis, (2021) , 170. 参考文献:10.1007/s11745-006-5124-4 摘要:Carballeira NM, Sanabria D, Cruz C, Parang K, Wan B, Franzblau S. 2,6-hexadecadiynoic acid and 2,6-nonadecadiynoic acid: novel synthesized acetylenic fatty acids as potent antifungal agents. Lipids. 2006 May;41(5):507–11.