CAS: 211427-08-6; Diquafosol (Tetrasodium)

专利信息

专利号:US-8288545-B2
优先权日:2006-07-21
标 题:Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
发明人：YANACHKOV IVAN; WRIGHT GEORGE E
权利人:YANACHKOV IVAN; WRIGHT GEORGE E; GLSYNTHESIS INC
摘要:This invention features bis-amides of pyrophosphoric acid and bisphosphonic acids, their preparation, and their use in synthesis of P 1 ,P 4 -dinucleoside tetraphosphates, tetraphosphonates, and related compounds.

专利号:US-8193338-B2
优先权日:2006-07-26
标题:Process for producing di(pyrimidine nucleoside 5'-)polyphosphate
发明人：KOGO SATORU; YAMADA KOHEI; IWAI YUKO; OSAWA KAZUOMI; HAYAKAWA HIROYUKI
权利人:KOGO SATORU; YAMADA KOHEI; IWAI YUKO; OSAWA KAZUOMI; HAYAKAWA HIROYUKI; YAMASA CORP
摘要:A di(pyrimidine nucleoside 5′-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5′-triphosphate into a pyrimidine nucleoside 5′-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5′-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron. Through the method of the invention, a di(pyrimidine nucleoside 5′-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5′-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5′-)polyphosphate.

专利号:US-2017159112-A1
优先权日:2015-12-02
标 题:Amplified isothermal detection of polynucleotides with atp release
发明人：KOOL ERIC T; JI DEBIN; MOHSEN MICHAEL G
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The presence of a target polynucleotide sequence of interest, including targets comprising genetic variations or a single nucleotide polymorphism, is detected by a DNA polymerization reaction, where the reaction mixture includes mixtures of nucleotides including at least one chimeric nucleoside tetraphosphate dimer ATP-linked nucleotide (ARN), in which ATP is the leaving group. DNA synthesis with ARNs is shown to be sequence specific, based on priming with a primer or template complementary to a target sequence. The released ATP is assayed in a qualitative or quantitative analysis, where one equivalent of ATP is released for every deoxynucleotide incorporated from an ARN.

专利号:CN-114195841-A
优先权日:2021-12-22
标题 :Synthesis method of diquafosol sodium