CAS: 190656-01-0; (9H-Fluoren-9-yl)Methyl Hydroxycarbamate

上下游产品

氯甲酸-9-芴基甲酯 (Fluorenylmethoxy)Carbonyl Chloride 28920-43-6
9-芴甲基-N-琥珀酰亚胺基碳酸酯 N-(9H-Fluoren-2-Ylmethoxycarbonyloxy)Succinimide 82911-69-1

📜氯甲酸-9-芴基甲酯置于盐酸羟胺,Sodium Hydroxide体系中,用 水 用作溶剂,以91 %的收率获得(9-芴基)甲基 N-羟基氨基甲酸酯
参考文献:通用性驱动的催化剂开发:用于对映选择性硝基烯烃还原的通用催化剂
标题:通用性驱动的催化剂开发:用于对映选择性硝基烯烃还原的通用催化剂
摘要:破解选择性-通用性悖论是不对称催化中最紧迫的挑战之一.这一障碍阻碍了新方法立即成功地转化为不同的小分子.这对于治疗开发来说尤其是限制速度,因为可用性和结构多样性往往是成功活动的关键组成部分.在这里,我们描述了通用性驱动的对映选择性催化和多种肽模拟物的制备的结合.单一的新型有机催化剂提供了只有金属和有机催化剂的组合才能匹配的高选择性和底物通用性.在有机催化领域,这一发现打破了 16 年的整体范式,揭示了一种强大的新支架,用于对映选择性还原,其行为表明可以识别硝基乙烯最小亲催化化合物.
Doi:10.1021/jacs.3C12436

专利信息

专利号:US-2008287649-A1
优先权日:2006-12-29
标 题 :Methods for the synthesis of cyclic peptides
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

专利号:EP-1960423-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-7544665-B2
优先权日:2004-12-30
标题 :Synthesis using peptide intermediate fragments
发明人：KHATRI HIRALAL N; HAN YEUN-KWEI; JOHNSTON DAVID A; HODGES L MARK
权利人:ROCHE COLORADO CORP
摘要:Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-8227571-B2
优先权日:2007-12-11
标题 :Insulinotropic peptide synthesis using solid and solution phase combination techniques
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R; ROCHE PALO ALTO LLC
摘要:The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybridâ€?) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to the third fragment which is then coupled to the second fragment and then the first fragment in solution. Alternatively, a different second fragment is coupled to the first fragment in the solid phase. Then, solution phase chemistry is then used to add additional amino acid material to a different third fragment. Subsequently, this different third fragment is coupled to the coupled first and different second fragment in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to the other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counteparts.

专利号:US-7820858-B2
优先权日:2006-03-25
标 题 :Concise β2-amino acid synthesis via organocatalytic aminomethylation
发明人：CHI YONGGUI; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; HORNE WILLIAM S; GUO LI; ENGLISH EMILY P
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides a method for the synthesis of β 2 -amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β 2 -amino acids.

专利号:US-8378066-B2
优先权日:2007-10-27
标 题 :Insulinotropic peptide synthesis using solid and solution phase combination techniques
发明人：KING BARRY THOMAS; BURY PAUL ADAM; GABEL RICHARD A; CRIDER JOHN EDWARD; CARR II ROBERT THAD; DEHOFF BRADLEY S
权利人:CORDEN PHARMA COLORADO INC; KING BARRY THOMAS; BURY PAUL ADAM; GABEL RICHARD A; CRIDER JOHN EDWARD; CARR II ROBERT THAD; DEHOFF BRADLEY S
摘要:The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybridâ€?) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as Exenatide(1-39) and its natural and non-natural counterparts.