CAS: 175204-82-7; Methyl 4-(Trifluoromethyl)Nicotinate

相似化合物

158063-66-2 1083197-78-7 198401-76-2

上下游产品

CAS号158063-66-2 4-三氟甲基烟酸 | CAS号74-88-4 碘甲烷 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号198401-76-2 (4-三氟甲基-3-吡啶)-甲醇

Methyl 3-(4,4,4-Trifluoro-3-Oxo-1-Butenylamino)Acrylate置于盐酸体系中,用 甲醇,Li2Co3 用作溶剂,化学反应生成4-(三氟甲基)烟酸甲酯
参考文献:Preparation Of 4-Haloalkylnicotinic Esters
标题:Preparation Of 4-Haloalkylnicotinic Esters
摘要:一种制备式(I)的4-卤代烷基烟酸酯的方法,其中rf为(C1-C4)卤代烷基,R为(C1-C6)烷基,包括以下步骤: A)在减压下用式(II)的氨基酮与式(III)至(V)的化合物进行缩合反应,其中 (R1Z)Ch═ch-coor (III),(R1Z)2Ch-ch2-coor (Iv),Hc≡c-coor (V),R1为(C1-C6)烷基,Z为o,S,Nr1或c(O)O,得到式(Vi)和/或(Vii)的化合物: Rf-c(O)-ch═ch-nh-ch═ch-coor (Vi) Rf-c(O)-ch═ch-nh-ch(Zr1)-ch2-coor (Vii) B)将反应产物进行环合反应.

专利信息

专利号:US-5756497-A
优先权日:1996-03-01
标题 :Tocolytic oxytocin receptor antagonists
发明人：BELL IAN M; FREIDINGER ROGER M; WILLIAMS PETER D
权利人:MERCK & CO INC
摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.