CAS: 1752-96-1; N-Phenylnicotinamide
该化合物是一种有机化合物,属于氨化物类别,其特征是存在尼古丁酸碱和厌食性组,具有独特的化学特性;该化合物一般是固体,在有机溶剂中溶解,反映氨化碳功能组的极性;尼氯硝基胺因其生物活动而在各个领域,包括制药和农用化学品的潜在用途而闻名;它可能具有抗微生物或抗炎作用等特性,因此值得进一步研究;此外,其结构允许进行可能的修改,以提高其功效或改变其溶性;与许多化学物质一样,处理尼氯氰化物需要适当的安全措施,以减少其使用可能带来的危害;总的来说,尼氯尼基尼,由于其多种功能特性,它是一种对合成化学和应用化学的兴趣复合物.
- 英文名称N-Phenylnicotinamide
- 中文名称N-苯基烟酰胺
- IUPAC名称N-phenylnicotinamide
- 其它别名Nicotinanilide(6CI,7CI,8CI); 3-Phenylamin°Carbonylpyridine; 3-Pyridylcarboxanilide; N-Phenyl-3-pyridinecarboxamide; N-Phenylnicotinamide
- CAS编号1752-96-1
- MFCD编号:MFCD00023572
- EINECS号:217-138-4
- FDA UNII编号:88DL247U5Q
- 分子式:C12H10N2O分子量:198.23
- 产品CID: 895638
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
69135-90-6 19060-64-1 63556-12-7物理性质
- 熔点114-118 °C
- 沸点265.8±13.0 °C at 760 mmHg
- 闪点114.5±19.8 °C
- 密度1.2±0.1 g/cm3
- pKa:12.28±0.70(预测)
- PSA:41.99
- LogP:2.3339
- 折射率1.650
- 蒸汽压0.0±0.5 mmHg at 25°C
- 溶解性Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- 敏感性常温常压稳定；避免与氧化物接触
- 外观形态固体
- 储存条件密封, 常温干燥保存
- 产品应用该化合物用作在0.4-1.0毫克/升的有效浓度下消灭ONCOMELANIA蜗牛;它也显示对蜗牛蛋有亲子活动,并有效对付其他软体动物,如贝拉米亚蜗牛和兰氏螺双叶;配制成硫酸盐或盐酸盐,以提高水溶性;显示高度稳定,在阳光照射后不丧失软体杀效,并且至少保持田地效力10天;对鱼类,水生植物,浮游生物(鱼类食物)和稻草的毒性较低.
- 性质描述烟酰苯胺(1752-96-1)的性状:本品的熔点是114-118°C.
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Warning(警告)
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
- UN编号NONH for all modes of transport
- 危险品标志Xi
- 安全声明26-36
- 危险类别码36/37/38
- WGK Germany3
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号626-60-8 3-氯吡啶 | CAS号201230-82-2 carbon monoxide | CAS号98-92-0 烟酰胺 | CAS号98-95-3 硝基苯 | CAS号591-50-4 碘苯 | CAS号1120-90-7 3-碘吡啶 | CAS号20260-53-1 盐酸烟酰氯 | CAS号108-86-1 溴苯 | CAS号108-90-7 氯苯 | CAS号88329-57-1 N,4-diphenylpyr... | CAS号88329-58-2 4-methyl-N-phen... | CAS号88329-59-3 4-butyl-N-pheny... | CAS号89565-39-9 N-[4-(dimethyls... | CAS号89565-40-2 N-(4-morpholin-... | CAS号89565-41-3 N-[4-(hydrazine...合成工艺路线路线简述
- 合成目标产物 Nicotinanilide 主要起始原料 Nicotinic Acid And Aniline
- (文献来源)合成步骤主要原料 Nicotinic Acid 和 Aniline
📜2,3-吡啶二羧酸酐置于苯体系中,化学反应生成烟酰苯胺
参考文献:Dimitrijevic; Tadic,Glasnik Hemijskog Drustva Beograd,1954,Vol. 19,P. 33,41
标题:Dimitrijevic; Tadic,Glasnik Hemijskog Drustva Beograd,1954,Vol. 19,P. 33,41
海关参考信息
- 2912110000-甲醛
2933310010-吡啶
2924199090-其他无环酰胺
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
专利号:US-7151112-B1
优先权日:2001-09-04
标题:Pharmaceutical uses and synthesis of nicotinamides
发明人：CUTSHALL NEIL S; JEFFREY SCOTT C
权利人:UCB SA
摘要:This invention is directed to methods of using a compound of the formula n nand pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating inflammatory events in an animal subject.
专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:WO-02053544-A1
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-n-oxides
专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Copper-Catalyzed Regioselective Synthesis OfN-Aryl Amides From Aldoximes And Aryl Halides作者:Niranjan Panda,Raghavender Mothkuri,Dinesh Kumar Nayak |发布日期:2014.3
摘要:Ligand-Assisted Copper-Catalyzed Reaction Of Aldoximes With Aryl Halides Is Described For The Regioselective Synthesis Of N-Aryl Amides. This Protocol Is Simple And Compatible With A Wide Range Of Functional Groups Attached To The Aryl Ring Of The Halides As Well As Aldoximes.
合成参考文献
摘要:Neumann, H.; Schranck, J., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 74.
摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 367.
摘要:Li, H.; Wang, Y.; Liu, Q., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 551.
参考文献:10.1038/nchem.1506
摘要:Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem. 2013 Jan;5(1):21–8. doi: 10.1038/nchem.1506.
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