CAS: 16105-78-5; N-Ethylamphetamine Hydrochloride

英文名称N-Ethylamphetamine Hydrochloride
中文名称(±)-N-乙基-α-甲基苯乙胺盐酸盐
IUPAC名称N-ethyl-1-phenylpropan-2-amine;hydrochloride
其它别名Benzeneethanamine,N-ethyl-a-methyl-, hydr°Chloride (9CI); Benzeneethanamine, N-ethyl-a-methyl-, hydr°Chloride, (?à)-; Phenethylamine, N-ethyl-a-methyl-, hydr°Chloride, (?à)- (8CI); (?à)-Ethylamphetaminehydr°Chloride; (?à)-N-Ethylamphetaminehydr°Chloride; Apetinil Depo; Ethylamphetamine hydr°Chloride; N-Ethylamphetamine hydr°Chloride; d,1-N-Ethyl amphetaminehydr°Chloride; dl-N-Ethylamphetamine hydr°Chloride
CAS编号16105-78-5
MFCD编号:MFCD01708141
EINECS号:240-270-9
FDA UNII编号:ZD9V2BK5GY
分子式:C11H17N.ClH分子量:199.72
产品CID: 812568
产品分类有机原料 → 苯类化合物 → 苯取代衍生物

相似结构搜索
InChIKey: HFBTZBOJTFIRAS-UHFFFAOYNA-N
1S/C11H17N.ClH/c1-3-12-10(2)9-11-7-5-4-6-8-11;/h4-8,10,12H,3,9H2,1-2H3;1H
计算化学: 氢键受体数1.0氢键供体数2.0可旋转键数4.0

物理性质

熔点145-146 °C
沸点No date available
闪点95.5 °C
密度3>g/ cm3
PSA:12.03
LogP:3.42
溶解性DMF: 3 mg/mL; DMSO: 5 mg/mL; Ethanol: 20 mg/mL; Pbs (Ph 7.2): 5 mg/mL
外观形态结晶性固体
储存条件2-8°C

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

ethylamine 1-phenyl-acetone

合成工艺路线路线简述

合成目标产物 (+/-)-N-Ethyl-Alpha-Methylphenethylamine Hydrochloride 主要起始原料 Ethylamine And Phenylacetone
(文献来源)合成步骤主要原料 Ethylamine 和 Phenylacetone

📜乙胺,苯基丙酮置于platinum(Iv) Oxide 盐酸,氢气体系中,用乙醇用作溶剂,化学反应 24.0H,以88%的收率获得(+/-)-N-乙基-Alpha-甲基苯乙胺盐酸盐
参考文献:Involvement Of Cyp2D6 In The In Vitro Metabolism Of Amphetamine,Two N-Alkylamphetamines And Their 4-Methoxylated Derivatives
标题:Involvement Of Cyp2D6 In The In Vitro Metabolism Of Amphetamine,Two N-Alkylamphetamines And Their 4-Methoxylated Derivatives
摘要:1. Amphetamine (Am) And Five Amphetamine Derivatives,N-Ethylamphetamine (Nea),N-Butylamphetamine (Nba),4-Methoxyamphetamine (Ri-Am),4-Methoxy-N-Ethylamphetamine (M-Nea) And 4-Methoxy-N-Butylamphetamine (M-Nba) Were Incubated With Microsomal Preparations From Cells Expressing Human Cyp2D6 To Determine Whether The Enzyme Was Capable Of Catalyzing The Direct Ring Oxidation Of All Substrates; The N-Dealkylation Of Nea,Nea,M-Nea And M-Nba; And The O-Demethylation Of M-Am,M-Nea And M-Nba.2. None Of The Six Compounds Examined Was N-Dealkylated To Any Extent.3. The Only Metabolites Produced From,Am,Nea And Nea Were The Corresponding Ring 4-Hydroxylated Compounds,And The Rates Of Formation Were Low.4. All Ring L-Methoxylated Substrates Were Efficiently O-Demethylated By Cyp2D6 To Their Corresponding Phenols. The Size Of The N-Alkyl Group Influenced The Rates Of Formation Of These Phenolamines. In Contrast To Reported Findings With 2-And 3-Methoxyamphetamines,None Of The 4-Methoxyamphetamines Was Ring-Oxidized In The Cyp2D6 Enzyme System To 2-Or 3-Hydroxy-4-Methoxyamphetamines Or To Dihydroxy-Amphetamines.
Doi:10.1080/004982599238344