CAS: 146-54-3; Triflupromazine
该化合物是一种苯并氨衍生化合物,具有三氟甲基替代成分和三级矿物质成分,其结构表明在制药或材料科学应用方面的潜在效用,特别是由于三氟甲基组的电排淡特性,这可能会增强稳定性或调节再活性.二甲基氨丙基磺酰侧链可能会造成溶解性或成为进一步衍生的功能处理器.鉴于苯并呋喃已知的药理学相关性,该化合物可能对生物活性分子的开发具有兴趣.由于存在反应性功能组,因此建议谨慎处理.需要进一步定性以确认具体应用.
- 英文名称Triflupromazine
- 中文名称三氟丙嗪
- IUPAC名称N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
- 其它别名dimethyl(3-(2-trifluoromethylphenothiazin-10-yl)propyl)amine; fluopromazine; triflupromazine; trifluoropromazine; 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)-10h-phenothiazine; trifluopromazine; vetame; n,n-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
- CAS编号146-54-3
- MFCD编号:MFCD00866708
- EINECS号:205-673-6
- FDA UNII编号:RO16TQF95Y
- 分子式:C18H19F3N2S分子量:352.423
- 产品CID: 698340
- 产品分类原料药 → 神经系统用药 → 抗精神病药
物理性质
- 熔点25 °C
- 沸点427.6 °C at 760mmHg
- 闪点212.4 °C
- 密度1.238g/cm3
- pKa:pKa 9.41(H2O (extrap) t = 24±1 I～0.002) (Uncertain)
- PSA:31.78
- LogP:5.3248
- 折射率nD23 1.5780
- 溶解性PRACTICALLY INSOL IN WATER
- 敏感性1、201甲基硅油一、性能特点：本品是一种无色透明的新型合成高分子材料，有多种不同的粘度（10CS～10800万CS）,从极易流动的液体到稠厚的半固态物。本品具有特殊的滑爽性、柔软性、憎水性，良好的化学稳定性、优异的电绝缘性和耐高低温性。闪点高、凝固点低，可在-50°C～+200°C下长期使用，粘温系数小、压缩率大，表面张力低，憎水防潮性好，比热导热系数小。
- 外观形态VISCOUS, LIGHT AMBER-COLORED, LIQ, WHICH CRYSTALLIZES ON PROLONGED STANDING INTO LARGE IRREGULAR CRYSTALS
- 储存条件1．本品应于常温下密闭贮存于干燥环境通风处，避免与酸、碱类物质接触，2．按非危险物品贮存、运输。
MSDS等安全信息
- GHS象形图
- GHS符号GHS08 & GHS06;
注释: Health hazard & Skull and crossbones - 危险类别致癌性 类别2
急性毒性 类别3(吸入)
急性毒性 类别3(经皮)
急性毒性 类别3(经口) - 警示词Danger(危险)
- 危险描述H351 |怀疑致癌.
H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒. - 防范说明P203, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P361+P364, P403+P233, P405, and P501
- 安全声明Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT<sub>2B</sub>).
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
2-(trifluoromethyl)-10H-phenothiazine 3-(Dimethylamino)propyl chloride N-(3-trifluoromethylphenyl)aniline o-bromothiophenolformaldehyd合成工艺路线路线简述
📜间三氟甲基二苯胺置于碘,Sulfur体系中,化学反应生成三氟丙嗪
参考文献:Yale Et Al.,Journal Of The American Chemical Society,1957,Vol. 79,P. 4375,4377
标题:Yale Et Al.,Journal Of The American Chemical Society,1957,Vol. 79,P. 4375,4377
海关参考信息
- 2902300000-甲苯
2921440000-二苯胺
2903399090-其他无环烃卤化衍生物
2930909099-其他有机硫化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).
专利号:US-2012232225-A1
优先权日:2009-08-26
标 题:Synthesis and isolation of dendrimer systems
发明人：BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL
权利人:BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).
专利号:US-9402911-B2
优先权日:2011-12-08
标题:Multifunctional small molecules
发明人：BAKER JR JAMES R; HUANG BAOHUA M; THOMAS THOMMEY P
权利人:UNIV MICHIGAN REGENTS
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.
专利号:US-8912323-B2
优先权日:2009-10-30
标题 :Multifunctional small molecules
发明人：BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P
权利人:BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P; UNIV MICHIGAN
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.
专利号:US-2014303123-A1
优先权日:2011-11-22
标 题:Synthesizing functionalized dendrimers within biological settings
发明人：BAKER JR JAMES R; GOONEWARDENA SASCHA NILU; ZONG HONG
权利人:UNIV MICHIGAN
摘要:The present invention relates to compositions (e.g., dendrimer scaffolds) capable of click chemistry for use in synthesis of functionalized dendrimers within biological settings, and methods of use of the same.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1038/cddis.2011.62
摘要:Zong D, Hååg P, Yakymovych I, Lewensohn R, Viktorsson K. Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation. Cell Death & Disease. 2011 Jul 21;2(7):e181. doi: 10.1038/cddis.2011.62.
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