CAS: 14438-32-5; 2-Amino-3,5-Dimethylbenzoic Acid

该化合物是一种替代苯并酸衍生物,在芳香环的2,3和5个位置有氨基和甲基功能组,该化合物是有机合成的多种中间体,特别是在制药,农用化学品和特殊化学品的制备方面.其结构特性,包括电子捐赠的甲基组和活性氨基甲基苯甲酸,使其对进一步功能化,例如恐吓或异氧循环形成具有价值.该化合物在极地有机溶剂中表现出中等溶性,便于在各种反应条件下使用.其定义明确的晶体结构确保了一致性和稳定性,支持可复制的合成应用.

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合成工艺路线路线简述

    📜3,5-二甲基苯甲酸置于硫酸,Palladium 10% On Activated Carbon,硝酸,溶剂黄146体系中,用 乙醇 用作溶剂,化学反应 27.0H,反应生成3,5-二甲基-2-氨基苯甲酸
    参考文献:N-芳基取代基上的侧链烷氧基提高了咪唑基亚烷基催化剂对enal和aldehyde的均烯酸酯环化反应的效率.
    标题:N-芳基取代基上的侧链烷氧基提高了咪唑基亚烷基催化剂对enal和aldehyde的均烯酸酯环化反应的效率.
    摘要:由咪唑基亚烷基催化剂和α,β-不饱和醛在四面体中间体中进行的氢转移形成了共轭breslow中间体.这是关键步骤,它通过向芳基醛中添加均烯酸酯来影响nhc催化的γ-丁内酯的形成效率.一种新型的邻位烷氧基侧基的咪唑基亚烷基催化剂描述了-N-芳基.这种催化剂有助于形成共轭的breslow中间体.对提供γ-丁内酯的均烯酸酯环化反应速率常数的研究表明,在n-芳基取代基的适当位置引入氧原子可以提高咪唑基亚烷基催化剂的效率.结构和机理研究表明,烷氧基侧基可以靠近四面体中间体的质子,从而促进质子转移.
    Doi:10.1002/anie.202008631

    海关参考信息

    专利信息


    专利号:US-5783577-A
    优先权日:1995-09-15
    标题 :Synthesis of quinazolinone libraries and derivatives thereof
    发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

    专利号:WO-9811438-A1
    优先权日:1996-09-13
    标题 :Synthesis of quinazolinone libraries and derivatives thereof

    专利号:US-7071145-B2
    优先权日:2001-09-25
    标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material
    发明人:MORITA MITSUNOBU; HAYAKAWA KUNIO; TORII MASAFUMI; NARUSE MITSURU
    权利人:RICOH KK
    摘要:A thermosensitive recording material comprising a thermosensitive layer provided on a substrate, and the thermosensitive layer comprises as main ingredients a leuco dye and a developer to make colored state of said leuco dye when heated, wherein the developer is an oligomer composition obtained from the reaction of a polyvalent isocyanate compound represented by following Formula (I) with an aromatic amine represented by following Formula (II); n nwhere X represents a try- or more-valent group, a represents an integer numeral of 3 or more, b and c represent respectively integer numerals in the range of 0 to 5 and they satisfy a relation of b+c=1 to 5, Z represents hydrogen atom, alkyl group, allyl group or aryl group, and the aryl group may include condensed ling structure thereof, and d represents an integer numeral in the range of 0 to 4. This developer shows excellent reliabilities of both image and background area, and also shows an excellent color-developing characteristics (color developing sensitivity and image density).

    专利号:US-2003153460-A1
    优先权日:2001-09-25
    标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material

    专利号:CN-115010671-A
    优先权日:2022-07-20
    标题:One-step synthesis method of 2-substituted quinazolinone

    专利号:US-2005079976-A1
    优先权日:2001-09-25
    标题 :Thermosensitive recording material, and synthesis method of oligomer composition for the recording material

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1016/j.bbrc.2023.08.050
    摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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