CAS: 142-08-5; Pyridin-2(1H)-One

上下游产品

CAS号13161-30-3 2-羟基吡啶-N-氧化物 | CAS号40673-25-4 4-氯-2-羟基吡啶 | CAS号109-04-6 2-溴吡啶 | CAS号1212-29-9 N,N'-二环己基硫脲 | CAS号1628-89-3 2-甲氧基吡啶 | CAS号120-57-0 胡椒醛 | CAS号1219454-89-3 二氟甲基2-吡啶基砜 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号66-99-9 2-萘甲醛 | CAS号100-10-7 对二甲氨基苯甲醛 | CAS号108664-25-1 1-[3-(2-methoxy... | CAS号104940-96-7 1-[3-(4-chlorop... | CAS号104941-02-8 1-[3-(4-chlorop... | CAS号104941-03-9 1-[1-(4-chlorop... | CAS号104940-99-0 1-[3-(2,4-dichl... | CAS号108664-23-9 1-(3-oxo-3-phen... | CAS号32111-34-5 4-(2-吡啶基)苯甲腈 | CAS号372-48-5 2-氟吡啶 | CAS号5006-66-6 6-羟基烟酸 | CAS号58530-50-0 2-(2-吡啶氧基)乙酸

2-甲氧基吡啶置于l-Selectride体系中,用 四氢呋喃 用作溶剂,化学反应 8.0H,以82%的收率获得2-羟基吡啶
参考文献:甲氧基吡啶的化学选择性去甲基化
标题:甲氧基吡啶的化学选择性去甲基化
摘要:已经开发了各种甲氧基吡啶衍生物的化学选择性去甲基化方法.在thf中用l-Selectride在回流温度下处理4-甲氧基吡啶2小时,以非常好的收率获得4-羟基吡啶;对苯甲醚没有反应.我们方法的效用通过抗溃疡剂奥美拉唑代谢物质的有效合成得到证明.在 4-甲氧基苯并咪唑的存在下实现了 3,5-二甲基-4-甲氧基吡啶位点的化学选择性去甲基化.
Doi:10.1055/s-0037-1612427

专利信息

专利号:US-9446995-B2
优先权日:2012-05-21
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-6376676-B1
优先权日:1993-06-30
标题 :Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; LIU HUI
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of novel intermediates in the synthesis of (±)-camptothecin and related compounds. The present synthesis scheme includes a novel 4+1 radical annulation followed by another cyclization to simultaneously assemble rings B and C of the camptothecin compound. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.