CAS: 138833-46-2; Fluorescein Octadecyl Ester

专利信息

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-8071132-B2
优先权日:2004-06-01
标 题:Unagglomerated core/shell nanocomposite particles
发明人：ADAIR JAMES H; ROUSE SARAH M; WANG JUN; KESTER MARK; SIEDLECKI CHRISTOPHER; WHITE WILLIAM B; VOGLER ERWIN; SNYDER ALAN; PANTANO CARLO G; RUIZ-VELASCO VICTOR; SINOWAY LAWRENCE
权利人:ADAIR JAMES H; ROUSE SARAH M; WANG JUN; KESTER MARK; SIEDLECKI CHRISTOPHER; WHITE WILLIAM B; VOGLER ERWIN; SNYDER ALAN; PANTANO CARLO G; RUIZ-VELASCO VICTOR; SINOWAY LAWRENCE; PENN STATE RES FOUND
摘要:The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.