4-异丙基苯甲酸置于sodium Metabisulfite,三氯氧磷体系中,化学反应生成4-异丙基苯甲腈 参考文献:The Electronic Properties Of Alkyl Groups. Ii. The Dipole Moments Of Alkyl Benzenes And Derivatives 标题:The Electronic Properties Of Alkyl Groups. Ii. The Dipole Moments Of Alkyl Benzenes And Derivatives 摘要: Doi:10.1021/ja01522A018
专利号:US-8106031-B2 优先权日:2006-05-02 标题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
专利号:US-8129520-B2 优先权日:2003-06-06 标题 :Methods and intermediates for the synthesis of dipyrrin-substituted porphyrinic macrocycles 发明人:YU LIANHE; MUTHUKUMARAN KANNAN; SREEDHARAN PRATHAPAN; LINDSEY JONATHAN S 权利人:YU LIANHE; MUTHUKUMARAN KANNAN; SREEDHARAN PRATHAPAN; LINDSEY JONATHAN S; UNIV NORTH CAROLINA STATE 摘要:The present invention provides dipyrrin substituted porphyrinic macrocycles, intermediates useful for making the same, and methods of making the same. Such compounds may be used for purposes including the making of molecular memory devices, solar cells and light harvesting arrays.
专利号:US-4536599-A 优先权日:1978-08-22 标题:Synthesis of amine derivatives 发明人:MASUKO FUJIO; KATSURA TADASHI 权利人:SUMITOMO CHEMICAL CO 摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.
专利号:WO-2021143617-A1 优先权日:2020-01-16 标题 :Cyclohexadiene oxime ether compound, synthesis method therefor and application thereof 发明人:DENG ZHAOXI; Hu Hewei; GUO SHAOXIONG; CEN JIN; TAN BIN; DU BINGBING; YANG LINA; LI JUNPEI 权利人:ZHENGZHOU INSTITUTE OF CHIRAL DRUGS RES CO LTD 摘要:The present invention provides a cyclohexadiene oxime ether compound having the following structural formula: (I) or (II) or (III); group R 1 and group R 3 are each selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, and a halogenated aromatic substituent or a cyano-substituted aromatic substituent; group R 2 is selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, a halogenated aromatic substituent, and a cyano-substituted aromatic substituent, a nitro-substituted aromatic substituent or a heterocyclic aromatic substituent; and the heterocyclic aromatic substituent is selected from (iv), (v) or (vi), wherein X is selected from -H, halogen, -CN, -NO 2 , and -CF 3 , -C(CF 3 ) 3 , and n is the number of substituents and is selected from 1, 2, and 3. The present invention also provides a preparation method for the above-mentioned cyclohexadiene oxime ether compound and an application thereof.
专利号:US-11858880-B2 优先权日:2017-06-16 标题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
专利号:US-11767302-B2 优先权日:2020-10-01 标题 :Reagents and methods for tetrazine synthesis 发明人:FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI 权利人:UNIV DELAWARE 摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.