CAS: 135459-90-4; Ranelic Acid

该化合物是一种化学化合物,主要在治疗与人体内氧化氮管制有关的条件方面,主要作为一种新型治疗剂,其特点是独特的结构,包括一个磺酸组和一个箱式酸组,有助于其在水中的溶解性和生物活动的潜力; 以其作为氮氧化物捐献者的作用而著称的,它可以影响各种生理过程,包括血管变异和...

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5-[双（2-乙氧基-2-氧乙基）氨基]-4-氰基-2-（甲氧基羰基）-3-噻吩乙酸甲酯 5-[bis(2-Ethoxy-2-Oxoethyl)Amino]-4-Cyano-2-(Methoxycarbonyl)-3-Thiopheneacetic Acid Methyl Ester 674800-87-4

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    📜5-[双(2-乙氧基-2-氧乙基)氨基]-4-氰基-2-(甲氧基羰基)-3-噻吩乙酸甲酯置于水,Lithium Hydroxide,硫酸体系中,用 四氢呋喃 用作溶剂,化学反应 22.0H,以95%的收率获得5-[二(羧甲基)氨基]-2-羧基-4-氰基-3-噻吩乙酸
    参考文献: Unsolvated Form Of Ranelic Acid And Process For Preparation Thereof[fr] Nouvelle Forme D'Acide Ranélique
    标题: Unsolvated Form Of Ranelic Acid And Process For Preparation Thereof[fr] Nouvelle Forme D'Acide Ranélique

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    专利信息


    专利号:US-7462714-B2
    优先权日:2002-09-24
    标题 :Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
    发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
    权利人:SERVIER LAB
    摘要:Process for the industrial synthesis of the compound of formula (I): n nApplication to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.

    专利号:US-7091364-B2
    优先权日:2002-09-24
    标题:Process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
    发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
    权利人:SERVIER LAB
    摘要:The process for the industrial synthesis of compounds of formula (I): n nwherein R and R′, which are the same or different, each represent linear or branched (C 1 –C 6 )alkyl.n n Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.

    专利号:US-7214805-B2
    优先权日:2002-09-24
    标题:Process for the industrial synthesis of strontium ranelate and its hydrates
    发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
    权利人:SERVIER LAB
    摘要:The process for the industrial The synthesis of strontium ranelate of formula (I): n nand its hydrates.

    专利号:US-8063100-B2
    优先权日:2007-09-26
    标 题 :Process for the synthesis of strontium ranelate and its hydrates
    发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
    权利人:VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL; SERVIER LAB
    摘要:A process for the industrial synthesis of strontium ranelate of formula (I): n nand its hydrates.

    专利号:US-2012123131-A1
    优先权日:2008-08-22
    标 题 :Process for the preparation of strontium ranelate
    发明人：PRABAHAR KOILPILLAI JOSEPH; KULKARNI PRAVIN BHALCHANDRA; PATIL PRASHANT BHASKARRAO; HIRE KAPIL RAMESH
    权利人:PRABAHAR KOILPILLAI JOSEPH; KULKARNI PRAVIN BHALCHANDRA; PATIL PRASHANT BHASKARRAO; HIRE KAPIL RAMESH
    摘要:The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula III, which is a useful intermediate in the synthesis of strontium ranelate. n n n n n n n n n n wherein R 1 and R 2 represents substituted or unsubstituted linear or branched C 1 -C 6 alkyl group or C 3 -C 12 cyclic group.

    专利号:US-5856356-A
    优先权日:1996-06-17
    标题:Use of strontium salts and pharmaceutical compositions thereof for the treatment of arthrosis
    发明人：TSOUDEROS YANNIS; DELOFFRE PASCALE; WIERZBICKI MICHEL
    权利人:ADIR
    摘要:The invention relates to the use of strontium salts and pharmaceutical compositions thereof for the treatment of arthrosis through stimulation of the synthesis of proteoglycans and type II collagen by chondrocytes.

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    主要参考文献


    1: Wang Q, Li ZS, Sun BW. Methyl 5-[N,N-bis-(methoxy-carbonyl-meth-yl)amino]-4-cyano-2-methoxy-carbonyl-3-thio-phe ne-ethan-o-ate. Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 13;64(Pt 10):o1927. doi: 10.1107/S1600536808028699.
    2: Deeks ED, Dhillon S. Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis. Drugs. 2010 Apr 16;70(6):733-59. doi: 10.2165/10481900-000000000-00000. Review. doi: 10.2165/11206440-000000000-00000. Review. Review. Review. German. Review.

    合成参考文献


    参考文献:10.1007/bf03327451
    摘要:Verhaar HJJ. Medical treatment of osteoporosis in the elderly. Aging Clinical and Experimental Research. 2009 Dec;21(6):407–13. doi: 10.1007/bf03327451.
    参考文献:10.1210/jc.2011-0593
    摘要:Carvalho NNC, Voss LA, Almeida MOP, Salgado CL, Bandeira F. Atypical Femoral Fractures during Prolonged Use of Bisphosphonates: Short-Term Responses to Strontium Ranelate and Teriparatide. The Journal of Clinical Endocrinology & Metabolism. 2011 Sep;96(9):2675–80. doi: 10.1210/jc.2011-0593.
    参考文献:10.1107/s1600536811010099
    摘要:Stahl K, Frankaer CG, Raffalt AC, Sørensen SR, Andersen JE. Polymeric strontium ranelate nona-hydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):m471–2.
    参考文献:10.1186/1471-2288-11-106
    摘要:Ramsay EN, Roughead EE, Ewald B, Pratt NL, Ryan P. A self-controlled case series to assess the effectiveness of beta blockers for heart failure in reducing hospitalisations in the elderly. BMC Medical Research Methodology. 2011 Jul 18;11(1):106. doi: 10.1186/1471-2288-11-106.
    参考文献:10.1016/j.joms.2011.02.093
    摘要:Vestergaard P, Schwartz K, Rejnmark L, Mosekilde L, Pinholt EM. Oral Bisphosphonate Use Increases the Risk for Inflammatory Jaw Disease: A Cohort Study. Journal of Oral and Maxillofacial Surgery. 2012 Apr;70(4):821–9. doi: 10.1016/j.joms.2011.02.093.
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