CAS: 130047-19-7; 4-Fluoro-2-(Trifluoromethyl)Phenol

该化合物是一种有机化合物,其特征是存在苯球氢氧基组和多种氟替代物,其分子结构的特征是:一个带有氟原子的酚环,其位置在准位置,而三氟甲基苯基则在正方位,相对于羟基组而言,具有氟原子具有独特的电子特性.该化合物一般没有色素,可被用于青黄固体,并因其在制药和农用化学品中的潜在用途而闻名.氟素的存在可增强化合物的脂性和稳定性,使其在各种化学反应和工艺中有用.此外,4-氟-2-(三氟甲基)苯酚可能展示出有趣的生物活动,尽管应考虑有关其毒性和环境影响的具体数据.与许多氟化化合物一样,必须谨慎处理,遵循适当的安全议定书,以减少与使用该化合物相关的健康或环境风险.

英文名称4-Fluoro-2-(Trifluoromethyl)Phenol
中文名称4-氟-2-(三氟甲基)苯酚
IUPAC名称4-fluoro-2-(trifluoromethyl)phenol
其它别名2-三氟甲基-4-氟苯酚; 2-(Trifluoromethyl)-4-Fluorophenol
CAS编号130047-19-7
MFCD编号:MFCD00061290
EINECS号:642-705-1
分子式:C7H4F4O
分子量:180.1
产品CID: 459064
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: RNOVGJWJVRESAA-UHFFFAOYSA-N
InChI=1S/C7H4F4O/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3,12H…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

243459-91-8 444-30-4 1214326-61-0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
危险等级8
UN编号3261.0
危险品标志T
风险等级Toxic
包装等级Ⅲ
安全声明26-36/37/39
危险类别码20/21/22-36/37/38

欧盟法规

C&L通报

合成工艺路线路线简述

1-(Benzyloxy)-4-Fluoro-2-(Trifluoromethyl)Benzene置于palladium 10% On Activated Carbon,Ammonium Formate体系中,用甲醇用作溶剂,化学反应 1.5H,反应生成4-氟-2-(三氟甲基)苯酚
参考文献:Syntheses And Bioactivity Of O-Or P-Trifluoromethylphenyl Phosphates
标题:Syntheses And Bioactivity Of O-Or P-Trifluoromethylphenyl Phosphates
摘要:O-And P-Trifluoromethylphenyl Phosphates Designed As Mechanism-Based Phosphotyrosine Phosphatase Inactivators Have Been Prepared. Some Of Them Show Herbicidal Activities.
Doi:10.1080/10426500802253090

海关参考信息

2902300000-甲苯
2907121100-间甲酚
2903399090-其他无环烃卤化衍生物
2908199090-其他酚的卤化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF Î²-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

专利号:US-9067934-B2
优先权日:2011-03-31
标题 :Bicyclic pyridinones
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:PT-951466-E
优先权日:1996-12-23
标题:CYTOALQUIL COMPOUNDS, LACTAMA, LACTONE AND RELATED, PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THE SAME, AND METHODS FOR INHIBITING Î’-AMYLOID PEPTIDE RELEASE AND / OR ITS SYNTHESIS BY THE USE OF SUCH COMPOUNDS