CAS: 129421-32-5; 2,3-Dihydro-1,4-Dioxino[2,3-B]Pyridine

该化合物是一种杂交有机化合物,其特点是独特的双环结构,其中含有一条环和一种二恶英.该化合物的特点是一个引信二恶英环系统,它有助于其化学再活性和潜在的生物活动.它一般是一种没有色素的黄色固体,在极地有机溶剂中表现出中等溶解性.在环中存在氮原子具有基本特性,而二恶英结构可以参与各种化学反应,包括电子生物替代和核生殖器攻击.由于其结构特征,2,2,3,3-二恶英[2,3-b] 可能会表现出有趣的药用化学特性.它的化学化学编号是129421-32-5,它很容易在化学数据库和文献中识别.总的来说,这种化合物的独特结构和潜在应用使得它成为有机和医学化学领域进一步研究的值得注意的主题.

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1417553-73-1 95897-49-7 1261365-65-4

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合成工艺路线路线简述

    📜3-Benzyloxy 2-Chloropyridine置于palladium On Activated Charcoal 偶氮二甲酸二异丙酯,氢气,Sodium Hydride,三苯基膦体系中,用 四氢呋喃,甲醇 用作溶剂,25.0~100.0 °C,310.27 Kpa 条件下,反应 18.5H,反应生成2,3-二氢-1,4-二并[2,3-B]吡啶
    参考文献:Joseph,Benoit; Benarab,Abdelhakim; Guillaumet,Gerald,Heterocycles,1994,Vol. 38,# 6,P. 1355-1360
    标题:Joseph,Benoit; Benarab,Abdelhakim; Guillaumet,Gerald,Heterocycles,1994,Vol. 38,# 6,P. 1355-1360

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    专利信息


    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-6127515-A
    优先权日:1997-11-18
    标 题:Functionalized resin for the synthesis of amides and peptides
    发明人：MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C
    权利人:AVENTIS PHARM PROD INC
    摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.

    专利号:US-6710208-B2
    优先权日:1996-12-19
    标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds
    发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
    权利人:AVENTIS PHARMA INC
    摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

    专利号:WO-2024112764-A1
    优先权日:2022-11-21
    标 题:Synthesis of pyrrolo[3,4-c]pyrroles
    发明人：LUKE GEORGE P; RODRIGUEZ SONIA; OUELLET STEPHANE G; GORINS GILLES; DIKER KHALID; BEAUDENON AURÉLIE; COUSIN JONATHAN
    权利人:NOVO NORDISK HEALTHCARE AG
    摘要:Novel synthetic methods of making pyrrolo[3,4- c ]pyrroles, derivatives thereof, and intermediates thereto are provided. Also provided are methods using pyrrolo[3,4- c ]pyrroles in the processes for preparing bioactive compounds ( e.g. PKR Activating Compounds).

    专利号:EP-4622958-A1
    优先权日:2022-11-21
    标 题 :Synthesis of pyrrolo[3,4-c]pyrroles

    专利号:EP-1200824-B1
    优先权日:1999-06-15
    标题:Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives

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    合成参考文献


    参考文献:10.1002/chir.20090
    摘要:Lazar S, Soukri M, El Haddad M, Akssira M, Leger JM, Jarry C, Morin P, Guillaumet G. Enantioselective synthesis of 2- and 3-substituted 2,3-dihydro[1,4]dioxino[2,3-b]pyridine derivatives and enantiomeric purity control by capillary electrophoresis. Chirality. 2005 Jan;17(1):30–6. doi: 10.1002/chir.20090.
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