CAS: 10488-69-4; Ethyl 4-Chloro-3-Hydroxybutanoate

相似化合物

86728-85-0 90866-33-4 638-07-3

上下游产品

CAS号638-07-3 4-氯乙酰乙酸乙酯 | CAS号67843-74-7 (S)-(+)-环氧氯丙烷 | CAS号64-17-5 乙醇 | CAS号201230-82-2 carbon monoxide | CAS号539-88-8 乙酰丙酸乙酯 | CAS号127913-44-4 (S)-4-氯-3-羟基丁腈 | CAS号93-55-0 苯丙酮 | CAS号136033-08-4 (R)-6-(3-chloro... | CAS号86728-85-0 (S)-3-羟基-4-氯丁酸乙酯 | CAS号112083-64-4 ethyl (3r)-3,4-... | CAS号6645-46-1 左旋肉碱盐酸盐 | CAS号22677-21-0 (R)-(+)-4-羟基-2-吡咯烷酮 | CAS号112083-63-3 (S)-2-环氧乙烷基乙酸乙酯 | CAS号139013-68-6 (S)-4-氯-1,3-丁二醇 | CAS号141942-85-0 (R)-(-)-4-氰基-3-... | CAS号10080-68-9 ETHYL (2E)-4-HY... | CAS号154026-92-3 6-氯-5(s)-羟基-3-氧... | CAS号125605-10-9 (R)-4-氯-1,3-丁二醇 | CAS号112100-39-7 S(-)-4-碘-3-羟基丁酸乙酯

4-氯乙酰乙酸乙酯置于ru((S)-Biaryl Diphosphine)Cl2(Dmf)N 氢气体系中,用 乙醇,二氯甲烷 用作溶剂,70.0 °C,344.75 Kpa 条件下,反应 24.0H,反应生成Dl-4-氯-3-羟基丁酸乙酯
参考文献:新型非对映体二膦配体的合成及其在不对称氢化反应中的应用.
标题:新型非对映体二膦配体的合成及其在不对称氢化反应中的应用.
摘要:[结构:见正文]合成了在主链上增加了手性中心的非对映体联芳基二膦配体10和11.在非对映体二膦氧化物的制备的偶联步骤中发生了底物定向的不对称合成.通过使用硅胶的柱色谱法容易地分离非对映体二膦氧化物.含有这些配体的钌催化剂在2-(6'-甲氧基-2'-萘基)丙酸和β-酮酸酯的氢化中非常有效.额外的手性中心对催化剂的对映选择性和活性有重大影响.
Doi:10.1021/ol026817+

专利信息

专利号:US-8269001-B2
优先权日:2005-10-05
标题 :Process for the synthesis of HMG-CoA reductase inhibitors
发明人：CASAR ZDENKO
权利人:CASAR ZDENKO; LEK PHARMACEUTICALS
摘要:A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-5292891-A
优先权日:1991-02-21
标 题 :Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound
发明人：KANEKO CHIKARA; SATO MASAYUKI
权利人:CHISSO CORP
摘要:There are provided novel and optically active 2,2-dimethyl-1,3-dioxin-4-ones which are useful as starting materials for physiologically active compounds, functional materials or the like. Provided are optically active 5,6-epoxyhexanoic acid esters and novel optically active 6-substituted tetrahydropyran-2-one derivatives. That is, optically active 6-chloromethyltetrahydropyran-2-one can be synthesized by lactonizing optically active 2,2-dimethyl-6-(3-chloro-2-hydroxypropyl)-1,3-dioxin-4-one to form optically active 6-chloromethyltetrahydropyran-2,4-dione; reacting the thus formed compound with hydrogen in the presence of a catalyst to obtain optically active 6-chloromethyl-4-hydroxytetrahydropyran-2-one; subjecting this compound to a dehydration reaction, thereby obtaining optically active 6-chloromethyldihydropyran-2-one; reacting this compound with hydrogen in the presence of a catalyst to form optically active 6-chloromethyltetrahydropyran-2-one; and then treating this compound under basic conditions to prepare an optically active 5,6-epoxyhexanoic acid ester represented by the formula (6) ##STR1## (wherein the symbol * represents an asymmetric carbon atom, and R is a methyl group or an ethyl group).

专利号:US-6800477-B2
优先权日:2001-03-22
标 题:Stereoselective reduction of substituted acetophenone
发明人：PATEL RAMESH; GOSWAMI ANIMESH; CHU LINDA N; NANDURI VENKATA B; GOLDBERG STEVEN L; JOHNSTON ROBERT M; DONOVAN MARY JO; MIRFAKHRAE K DAVID
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of gamma-secretase useful in the treatment of Alzheimer's disease.

专利号:US-7083973-B2
优先权日:2000-08-16
标题 :Stereoselective reduction of substituted oxo-butanes
发明人：PATEL RAMESH N; CHU LINDA
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium . The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.