CAS: 1023595-17-6; (1H-Indazol-4-yl)Boronic Acid

相似化合物

885618-33-7 885068-10-0 338454-14-1

上下游产品

boric acid tributyl ester2-amino-6-(1H-indazol-4-yl)-3-phenyl-4(3H)-quinazolinone

硼酸三丁酯,4-Bromo-1-(Triisopropylsilyl)-1H-Indazole置于正丁基锂体系中,化学反应 0.5H,以72%的收率获得1H-吲唑-4-硼酸
参考文献:一种氮未取代吡唑和吲唑类硼酸的制备方法
标题:一种氮未取代吡唑和吲唑类硼酸的制备方法
摘要:一种氮未取代吡唑和吲唑类硼酸的制备方法,以氮未取代卤代吡唑及其衍生物或氮未取代卤代吲唑及其衍生物和三异丙基氯硅烷溶于有机溶剂中进行反应,生成三异丙基硅基保护的卤代吡唑或者卤代吲唑化合物,再与正丁基锂发生锂溴交换反应,加入硼酸酯引入硼原子,水解后高收率的到得了氮未取代吡唑或吲唑类硼酸.

专利信息

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:US-8791131-B2
优先权日:2008-09-30
标题 :Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
发明人：CHENG HENGMIAO; JOHNSON TED WILLIAM; HOFFMAN JACQUI ELIZABETH; GUO LISA CHEN; LIU ZHENGYU
权利人:CHENG HENGMIAO; JOHNSON TED WILLIAM; HOFFMAN JACQUI ELIZABETH; GUO LISA CHEN; LIU ZHENGYU; PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to salts thereof, their synthesis, and their use as PI3-Kα inhibitors and/or PI3-Kα/mTOR dual inhibitors.