CAS: 98548-01-7; Ethyl 6-Aminopyridazine-3-Carboxylate

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59772-58-6 98140-96-6 1314912-56-5

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6-chloro-3-pyridazinecarboxylic acid ethyl ester 6-aminopyridazine-3-carboxylic acid methyl ester ethanol ethyl 2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazine-6-carboxylate

📜6-氯哒嗪3-羧酸乙酯置于盐酸,Sodium Azide体系中,用 二甲基亚砜 作为反应溶剂,化学反应 2.0H,反应生成 6-氨基哒嗪-3-甲酸乙酯
参考文献:Highly Efficient One-Pot Amination Of Carboxylate-Substituted Nitrogen-Containing Heteroaryl Chlorides Via Staudinger Reaction
标题:Highly Efficient One-Pot Amination Of Carboxylate-Substituted Nitrogen-Containing Heteroaryl Chlorides Via Staudinger Reaction
摘要:An Efficient One-Pot Method For The Synthesis Of Tert-Butyl 6-Aminonicotinate (5) Is Described. The Key Transformation Involves Displacement Of The Chloro Group In Tert-Butyl 6-Chloronicotinate (2) With Azide Followed By A Staudinger Reaction. The Scope Of This Methodology Is Further Extended For The Synthesis Of A Series Of Carboxylate-Substituted Heteroaryl Amines. In Particular,We Synthesized Tert-Butyl Carboxylate-Substituted Amino-Pyridine,-Pyridazine,And-Pyrazine. In Addition To One-Pot Conversion,Short Reaction Time,Simplicity Of Operation,Ease Of Purification,And Good Yields Are The Key Advantages Of This Methodology. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2012.11.027