CAS: 92-73-9; N-(2,5-Dimethoxyphenyl)-3-Hydroxy-2-Naphthamide

该化合物是一种属于氯化萘衍生物类别的化学化合物,其特点是存在一种环环环系统,代之以氢氧基和甲氧基,这对其化学特性和反应作用有帮助.该化合物一般在有机溶剂中表现出中等溶解性,由于其水溶性氯化萘结构,水溶性可能有限.该氢氧基组的存在可产生某种极性,影响其与其他物质的相互作用.3-Hydroxy-2',5'dimeththoxynaphnilide也可能表现出生物活动,使其对医药和药用化学感兴趣.其结构特征表明在各个领域的潜在应用,包括染色化学和有机合成的前体.与许多化学物质一样,应参考安全数据,以了解其处理,毒性和环境影响.

结构式图片

物理性质

MSDS等安全信息

上下游产品

3-Hydroxy-2-naphthoic acid 2,5-dimethoxyaniline 3-hydroxynaphthalene-2-carboxylic acid

合成工艺路线路线简述

  • 92-70-6 + 102-56-7 = 92-73-9
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
    标题:Consensus-Based Pharmacophore Mapping For New Set Of N-(Disubstituted-Phenyl)-3-Hydroxyl-Naphthalene-2-Carboxamides
    作者:Bak,Andrzej; Kos,Jiri; Michnova,Hana; Gonec,Tomas; Pospisilova,Sarka; Et Al
    参考文献:International Journal Of Molecular Sciences 日期:2020 卷标:21(18)]

    = 92-73-9 [标题:Reaction Conditions
    标题:Preparation Of Phenol Or Phenyl Acetate Derivatives As Therapeutic Drugs For Prevention Or Treatment Of Diabetes And/or Diabetes Complications
    参考文献:World Intellectual Property Organization]

    = 92-73-9 [标题:Reaction Conditions
    标题:Aryl Amides Of 2-Hydroxy-3-Naphthoic Acid
    参考文献:Czechoslovakia]

    92-70-6 + 102-56-7 = 92-73-9
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
    标题:Photosynthesis-Inhibiting Activity Of Methoxy-Substituted 3-Hydroxynaphthalene-2-Carboxanilides
    作者:Kos,Jiri; Gonec,Tomas; Oravec,Michal; Jampilek,Josef
    参考文献:International Electronic Conference On Synthetic Organic Chemistry 日期:2020 卷标:1 页码:1-7]

    92-70-6 + 102-56-7 = 92-73-9
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
    标题:Photosynthesis-Inhibiting Activity Of N-(Disubstituted-Phenyl)-3-Hydroxynaphthalene-2-Carboxamides †
    作者:Kos,Jiri; Gonec,Tomas; Oravec,Michal; Jendrzejewska,Izabela; Jampilek,Josef
    参考文献:Molecules 日期:2021 卷标:26(14)]

    = 92-73-9 [标题:Reaction Conditions
    标题:Preparation Of Phenol Or Phenyl Acetate Derivatives For Treatment Of Allergic Diseases
    参考文献:World Intellectual Property Organization]

    = 92-73-9 [标题:Reaction Conditions
    标题:Preparation Of Phenol Or Phenyl Acetate Derivatives As Inhibitors Against The Activation Of Activator Protein-1 (Ap-1) And Nuclear Factor Of Activated T-Cells (Nfat)
    参考文献:World Intellectual Property Organization]

    = 92-73-9 [标题:Reaction Conditions
    标题:Benzamide,Naphthalenecarboxamide,Arylacetamide,Arenesulfonamide,Carbamate,Thiocarbamate,And Benzylamine Inhibitors Of Inosine-5'-Monophosphate Dehydrogenase
    参考文献:World Intellectual Property Organization
📜2-羟基-3-萘甲酸,2,5-二甲氧基苯胺置于三氯化磷体系中,用 氯苯 作为反应溶剂,化学反应 0.75H,以57%的收率获得产物色酚as-Bg
参考文献:新的n-(二取代-苯基)-3-羟基-萘-2-羧酰胺的基于共识的药理定位.
标题:新的n-(二取代-苯基)-3-羟基-萘-2-羧酰胺的基于共识的药理定位.
摘要:合成了一系列二十二种新颖的n-(二取代-苯基)-3-羟基萘-2-羧酰胺衍生物,并将其表征为潜在的抗菌剂.n-[3,5-双(三氟甲基)苯基]-和n-[2-氯-5-(三氟甲基)苯基]-3-羟基-萘-2-甲酰胺显示出对(ms 0.16-0.68 µm)的亚微摩尔活性耐甲氧西林金黄色葡萄球菌分离株.n-[3,5-双(三氟甲基)苯基]-和n-[4-溴-3-(三氟甲基)苯基]-3-羟基萘-2-羧酰胺显示出抗结核分枝杆菌的活性(两个mic均为10 µm)与利福平.观测到环丙沙星与n-[4-溴-3-(三氟甲基)苯基]-和n-(4-溴-3-氟苯基)-3-羟基萘-2-甲酰胺的组合对mrsa Sa 630分离物具有协同活性.使用主成分分析对结构相关的羧酰胺衍生物的同类系列进行相似性相关的属性空间评估.有趣的是,具有-Cf 3取代基的单卤代羧酰胺衍生物的不同分布伴随着增加的活性曲线.tanimoto
DOI:10.3390/ijms21186583

海关参考信息

专利信息


专利号:US-5243032-A
优先权日:1989-06-22
标题:Preparation of azo pigments with low pcb content by coupling in the presence of olefins
发明人：RIEPER WOLFGANG
权利人:HOECHST AG
摘要:The production which is customary in practice of monoazo compounds based on dichloro- and trichloroanilines or disazo compounds of the chlorinated biphenyl series by conventional coupling methods meets with difficulties in that the resulting pigments are contaminated by traces of polychlorinated biphenyls. n According to the invention, it has now been found that by addition of water-soluble olefins of the type ##STR1## (R =H, alk or Oalk; X =--COOR 1 , --CONHR 2 or --NR 3 COR 4 ) n in the azo coupling, the side reactions which form PCBs can be decidedly suppressed during synthesis of the pigments.

专利号:US-8445651-B2
优先权日:2008-10-23
标题 :Method for producing charge control agent and toner
发明人：ZHU SHUNQUAN; WANG YUBIN
权利人:ZHU SHUNQUAN; WANG YUBIN; HUBEI DINGLONG CHEMICAL CO LTD
摘要:The invention discloses a method for producing a charge control agent and a toner containing the charge control agent. The preparation method includes the technical proposal that in aqueous medium, an azo compound is reacted with a salicylic acid chromium complex, which is used as a complexing agent to synthesize a specific azo chromium complex. The preparation method is characterized by complex synthesis engineering. The toner of the invention includes a charge control agent obtained from the method described herein. Provided is a method for obtaining a charge control agent and a toner with excellent chargeability in that no flying or fogging is observed, even during image formation at high printing speeds. The toner is relatively free from the influences of variations in the environmental temperature and humidity, which ensures stable image printing with high picture quality for long periods of time.

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主要参考文献


1: Oturkar CC, Patole MS, R Gawai K, Madamwar D. Enzyme based cleavage strategy of Bacillus lentus BI377 in response to metabolism of azoic recalcitrant. Bioresour Technol. 2013 Feb;130:360-5. doi: 10.1016/j.biortech.2012.12.019. Epub 2012 Dec 14. doi: 10.1016/j.saa.2008.10.006. Epub 2008 Oct 21. doi: 10.1016/j.jhazmat.2009.01.105. Epub 2009 Feb 6. Italian. Italian. doi: 10.1016/j.jhazmat.2009.12.027. Epub 2009 Dec 16. French. doi: 10.1021/la901201s. Italian. doi: 10.1039/c3cp51581h. doi: 10.1021/es102884v. Epub 2010 Nov 9. doi: 10.1021/ic201224g. Epub 2011 Aug 16. Epub 2005 Apr 15.

合成参考文献


参考文献:10.1007/978-1-4615-6663-2_7
摘要:Allen RLM. Azoic dyes. 1971. In: Colour Chemistry.
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