CAS: 89581-84-0; 2-Chloro-3-(Chloromethyl)Pyridine

该化合物是一种多用途的七环环化合物,含有活性氯和氯甲基功能组,使其成为有机合成中有价值的中间体,其分子结构允许有选择地进行修改,便利在药品,农用化学品和特殊化学品中的应用.存在两个不同的反应场所,可以有效地衍生,包括核生殖替代或进一步功能化.该化合物在受控制的条件下表现出稳定性,确保工业流程的可靠处理.它在建造复杂的基框架方面的效用强调了其在药用化学和物质科学中的重要性.建议适当储存在冷干环境中以保持其完整性.

结构式图片

相似化合物

150807-88-8 1017782-64-7 70258-18-3

物理性质

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欧盟法规

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上下游产品

(2-chloropyrid-3-yl)methanol 2-chloro-3-carbaldehydepyridine nicotinic acid 2-Chloronicotinoyl chloride C-(2-chloro-pyridin-3-yl)-methylamine [2-(3-benzyl-phenyl)-2-oxo-ethyl]-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester H-[1,6]naphthyridine-6-carboxylic acid benzyl ester7-(3-benzyl-benzoyl)-8-oxo-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid benzyl ester 3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

合成工艺路线路线简述

  • 合成目标产物 2-Bromo-3-(Chloromethyl)Pyridine 主要起始原料 2-Chloro-3-Methylpyridine
  • 42330-59-6 = 89581-84-0
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 0 °C; 6 H,0 °C
    标题:Synthesis And Characterization Of 2-Chloro-3-Cyanomethylpyridine
    作者:Li,Yueqin; Tao,Xian; Xu,Huihua; Shen,Yingzhong
    参考文献:Jingxi Huagong 日期:2009 卷标:26(9) 页码:928-931]

    42330-59-6 = 89581-84-0
    反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C; 2 H,Rt
    标题:Fatty Acid Amide Hydrolase Inhibitors. 3: Tetra-Substituted Azetidine Ureas With In Vivo Activity
    作者:Roughley,Stephen D.; Browne,Helen; Macias,Alba T.; Benwell,Karen; Brooks,Teresa; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(2) 页码:901-906]

    82401-08-9 = 89581-84-0
    反应条件:1.1 Reagents: Phosphorus Oxychloride
    标题:Synthetic Medicinals. Viii. New-Type Tricyclic Thiazepine And Thiepin Derivatives
    作者:Gadient,F.; Jucker,E.; Lindenmann,A.; Taeschler,M.
    参考文献:Helvetica Chimica Acta 日期:1962 卷标:45 页码:1800-70]

    42330-59-6 = 89581-84-0
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 - 4 H,Rt
    标题:Structure-Guided Optimization Of 1H-Imidazole-2-Carboxylic Acid Derivatives Affording Potent Vim-Type Metallo-β-Lactamase Inhibitors
    作者:Yan,Yu-Hang; Li,Wenfang; Chen,Wei; Li,Chao; Zhu,Kai-Rong; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2022 卷标:228]

    42330-59-6 = 89581-84-0
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane,Toluene; 16 H,Rt
    标题:Discovery Of N-Substituted 7-Azaindoline Derivatives As Potent,Orally Available M1 And M4 Muscarinic Acetylcholine Receptors Selective Agonists
    作者:Takai,Kentaro; Inoue,Yasunao; Konishi,Yasuko; Suwa,Atsushi; Uruno,Yoshiharu; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2014 卷标:24(14) 页码:3189-3193
📜2-氯-3-吡啶甲醇置于吡啶,氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,以100%的收率获得产物2-氯-3-氯甲基吡啶
参考文献:杂环化中的分子内n-芳基化:新型吡啶基稠合的吡咯并[1,2-A] [1,4]二氮杂pin酮的合成
标题:杂环化中的分子内n-芳基化:新型吡啶基稠合的吡咯并[1,2-A] [1,4]二氮杂pin酮的合成
摘要:将1-脯氨酰胺与3-(氯甲基)-2-卤代吡啶烷基化,然后通过分子内pd催化的酰胺化反应进行环化,从而提供了吡啶并[2,3-E]吡咯并[1,2-A] [1,4] Diazepin-10-1支架.此外,通过用boc-1-脯氨酸对连续取代的(氨甲基)卤代吡啶进行酰化,然后再用boc-1-脯氨酸进行酰化反应,从而开发了一条合成途径,用于合成各种新的吡啶并[F]吡咯并[1,2-A] [1,4]二氮杂-7-酮.分子内胺化.
DOI:10.1016/j.Tetlet.2010.05.121

海关参考信息

专利信息


专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:US-6608202-B1
优先权日:2001-08-21
标题:Process of synthesis of a tricyclic ketone intermediate
发明人：DORAN HENRY J; O'NEILL PAT M; WILLIAMS ROBERT P
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen,and intermediates therefor from easily available starting materials by a simple route.

专利号:US-2022056008-A1
优先权日:2018-12-21
标 题:Process and intermediates for the synthesis of voxelotor
发明人：FERREIRO GIL JUAN JOSÉ; IGLESIAS RETUERTO JESÚS MIGUEL; LORENTE BONDE-LARSEN ANTONIO
权利人:CRYSTAL PHARMA SAU
摘要:The invention relates to a process for the preparation of Voxelotor, or a salt or solvate thereof, according to the following scheme (Formula 1).

专利号:US-2003144314-A1
优先权日:2001-08-21
标 题 :Process of synthesis of a tricyclic ketone intermediate

专利号:EP-1421068-B1
优先权日:2001-08-21
标题:A process of synthesis of a tricyclic ketone intermediate

专利号:CN-109232400-A
优先权日:2018-11-22
标 题 :A kind of method for continuous synthesis of 2,3-dichloro-5-trifluoromethylpyridine

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合成参考文献

参考DOI号:10.1016/j.tetlet.2010.05.121
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