CAS: 85466-66-6; N-Boc-N-Methyl-D-Phenylalanine

该化合物是受保护的氨酸衍生物,通常用于丙酸合成,一种以其芳香侧链为名的基本氨酸.该化合物通常用于聚氨酯和其他生物活性分子的合成,而氨基聚苯基和其他生物活性分子的保护对于控制反应路径至关重要.在各种条件下,氮原子的溶解性以及稳定性使该物质成为有机合成中有价值的中间体.与许多化学物质一样,妥善处理和安全防范是其使用的潜在危害所必不可少的.

结构式图片

物理性质

MSDS等安全信息

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate (S,S)-pseudoephedrine N-methyl-D-phenylalaninamide N-Methyl-L-phenylalanine (S)-N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-3-phenyl-propionamide(S)-2-[(R)-2-(tert-Butoxycarbonyl-methyl-amino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid methyl ester methyl-((1R)-2-phenyl-1-(((tetrahydrofuran-2-yl)methyl)carbamoyl)ethyl)carbamic acid tert-butyl ester ((R)-1-Ethylcarbamoyl-2-phenyl-ethyl)-methyl-carbamic acid tert-butyl ester N-Methyl-N-((R)-1-(methylcarbamoyl)-2-phenylethyl)carbamic acid tert-butyl ester

合成工艺路线路线简述

  • 18942-49-9 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; Overnight,Rt1.2 Reagents: Water; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
    标题:Synthesis And Structure Revision Of Symplocin A
    作者:Shao,Lu-Ping; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2017 卷标:4(6) 页码:995-1004]

    176199-35-2 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 24 H,Rt1.2 Solvents: Ethyl Acetate,Water
    标题:X-Ray Crystallographic Structure Of A Teixobactin Derivative Reveals Amyloid-Like Assembly
    作者:Yang,Hyunjun; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2018 卷标:140(43) 页码:14028-14032]

    24424-99-5 + 673-06-3 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; 10 Min,Ph 10.5,0 °C; 0 °C -> Rt; 24 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C2.1 Solvents: Tetrahydrofuran; 0 °C; 30 Min,0 °C2.2 Reagents: Sodium Hydride; 0 °C; 24 H,> 0 °C; 0 °C -> Rt; Overnight,Rt
    标题:D-Amino Acid Position Influences The Anticancer Activity Of Galaxamide Analogs: An Apoptotic Mechanism Study
    作者:Bai,Defa; Et Al
    参考文献:International Journal Of Molecular Sciences 日期:2017 卷标:18(3) 页码:544/1-544/19]

    673-06-3 = 85466-66-6
    反应条件:1.1 Reagents: Iodine,Sulfuric Acid,Sodium Iodate Solvents: Acetic Acid; 24 H,70 °C1.2 Reagents: Sodium Periodate; 24 H,70 °C1.3 Reagents: Potassium Hydroxide Solvents: Dichloromethane,Water; Ph 7,0 °C2.1 Reagents: Triethylamine Solvents: Methanol,Water; 16 H,55 °C3.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 24 H,Rt3.2 Solvents: Ethyl Acetate,Water
    标题:X-Ray Crystallographic Structure Of A Teixobactin Derivative Reveals Amyloid-Like Assembly
    作者:Yang,Hyunjun; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2018 卷标:140(43) 页码:14028-14032]

    18942-49-9 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 24 H,Rt; Rt -> 0 °C1.2 Reagents: Water; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Design,Synthesis And Biological Evaluation Of Tasiamide B Derivatives As Bace1 Inhibitors
    作者:Liu,Jian; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2015 卷标:23(9) 页码:1963-1974]

    24424-99-5 + 673-06-3 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 15 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,Rt1.3 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 2 H,0 °C; 19 H,0 °C1.4 Reagents: Water1.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 1
    标题:Structure-Activity Relationship Study Of Majusculamides A And B And Their Analogues On Osteogenic Activity
    作者:Natsume,Noriyuki; Et Al
    参考文献:Journal Of Natural Products 日期:2020 卷标:83(8) 页码:2477-2482]

    = 85466-66-6
    反应条件:1.1 Reagents: Sodium Periodate Catalysts: Ruthenium Trichloride Solvents: Carbon Tetrachloride,Acetonitrile,Water; 15 Min,Rt1.2 Solvents: Acetonitrile; 15 Min,Rt
    标题:Iridium-Catalyzed Asymmetric Hydrogenation Of N-Alkyl α-Aryl Furan-Containing Imines: An Efficient Route To Unnatural N-Alkyl Arylalanines And Related Derivatives.
    作者:Mazuela,Javier; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2019 卷标:361(3) 页码:578-584]

    24424-99-5 = 85466-66-6
    反应条件:1.1 Catalysts: 1,1′-Bis[(11Bs)-3,5-Dihydro-4H-Dinaphtho[2,1-C:1′,2′-E]Phosphepin-4-Yl]Ferrocene,Iridium(1+),Bis[(1,2,5,6-η)-1,5-Cyclooctadiene]-,Tetrakis[3,5-Bis(Trifluoromet... Solvents: Dichloromethane; 30 Min,Rt1.2 Reagents: Hydrogen Solvents: Dichloromethane; 16 H,30 Bar,Rt1.3 Overnight,Rt2.1 Reagents: Sodium Periodate Catalysts: Ruthenium Trichloride Solvents: Carbon Tetrachloride,Acetonitrile,Water; 15 Min,Rt2.2 Solvents: Acetonitrile; 15 Min,Rt
    标题:Iridium-Catalyzed Asymmetric Hydrogenation Of N-Alkyl α-Aryl Furan-Containing Imines: An Efficient Route To Unnatural N-Alkyl Arylalanines And Related Derivatives.
    作者:Mazuela,Javier; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2019 卷标:361(3) 页码:578-584]

    24424-99-5 + 62561-75-5 = 85466-66-6
    反应条件:1.1 Reagents: Triethylamine Solvents: Methanol,Water; 16 H,55 °C2.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 24 H,Rt2.2 Solvents: Ethyl Acetate,Water
    标题:X-Ray Crystallographic Structure Of A Teixobactin Derivative Reveals Amyloid-Like Assembly
    作者:Yang,Hyunjun; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2018 卷标:140(43) 页码:14028-14032]

    24424-99-5 + 673-06-3 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water2.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 1 H,Rt2.2 12 H,Rt2.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:Total Syntheses Of Cathepsin D Inhibitory Izenamides A,B,And C And Structural Confirmation Of Izenamide B
    作者:Lim,Changjin
    参考文献:Molecules 日期:2019 卷标:24(19)]

    24424-99-5 + 673-06-3 = 85466-66-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; 10 Min,0 °C; 0 °C -> Rt1.2 Overnight,Ph 10 - 11,Rt; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Cooled2.1 Solvents: Tetrahydrofuran; 0 °C; 30 Min,0 °C2.2 Reagents: Sodium Hydride Solvents: Water; 0 °C; 0 °C -> Rt; Overnight,Rt2.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 3,Cooled
    标题:Synthesis Of Two Galaxamide Analogues And Tentative Investigation Into Their Antitumor Activity
    作者:Qiu,Shao-Ling; Et Al
    参考文献:Jingxi Huagong 日期:2015 卷标:32(2) 页码:163-170

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合成方法参考DOI号:10.1002/hlca.201200519
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