专利号:US-8673885-B1 优先权日:2010-07-25 标 题 :Compounds for the protection of sulfur containing linkers in nucleic acid synthesis 发明人:DUFF ROBERT 权利人:DUFF ROBERT 摘要:Aromatic and alkyl thiocarbonates with and without a neighboring group that participates in the hydrolysis of a thiocarbonate are described. The aromatic or alkyl thiocarbonates can be used for the protection of sulfur during oligonucleotide synthesis. Their facile processes of manufacture and methods of using the same are provided.
专利号:US-2005148042-A1 优先权日:2002-03-29 标 题 :Hybrid phosphoinositide phospholipids: compositions and uses 发明人:PRESTWICH GLENN; RZEPECKI PIOTR W; FERGUSON COLIN G; NEILSEN PAUL O; BRANCH ANGIE M; CROSBY LEE R 摘要:The methods and compositions disclosed herein concern the synthesis of a novel class of “two-headedâ€? phospholipid-phosphoinositide hybrids possessing a carbon backbone, such as 2,3-diacylthreitol, erythritol or a synthetic module. The second phospholipid head group allows introduction of a biochemical or chemical moiety in a position orthogonal in space to those occupied by the phosphoinositide head group and the two acyl chains. The diacyl moieties allow for the incorporation of Pea-PIP 2 into a lipid bilayer, while the Ptdlns(4,5)P 2 moiety in the aqueous layer is specifically recognized by lipid binding proteins. In alternative embodiments of the invention, reporters, for example biotin, fluorophores and/or spin labels, are attached to the free amino group of the head groups of such molecules to specifically target the reporters to the lipid-water interface.
专利号:US-8450414-B2 优先权日:2007-01-30 标题 :Glycerol ester-free functionalized vegetable oil derivatives and their latex compounds 发明人:THAMES SHELBY F; RAWLINS JAMES W; MENDON SHARATHKUMAR K; DELATTE DAVID 权利人:THAMES SHELBY F; RAWLINS JAMES W; MENDON SHARATHKUMAR K; DELATTE DAVID; UNIV SOUTHERN MISSISSIPPI 摘要:The present invention is directed to a fatty amide (meth)acrylate monomer, methods of making the monomer, and latex polymers comprising the fatty amide (meth)acrylate monomer. The monomers are derived by reacting unsaturated vegetable oils with ethanolamine or substituted ethanolamine. The vegetable oil derivative is then reacted with either (meth)acryloyl chloride or (meth)acrylic acid to form a fatty amide (meth)acrylate monomer or the product of the reaction of hydroxyethyl (meth)acrylate reacted with isophorone diisocyanate to form a urethane fatty amide (meth)acrylate monomer. The increased hydrophilicity of the fatty amide (meth)acrylate monomer facilitates the diffusion through the aqueous phase. The monomer synthesis is designed to be glycerol ester-free to increase long term stability for monomers and polymers.
专利号:CN-115093365-A 优先权日:2022-07-25 标题:Synthesis method of lefenacin
专利号:CN-116813518-A 优先权日:2023-05-09 标 题 :Synthesis method of nemaltevir chiral intermediate
参考标题:Alkyl 1-Chloroalkyl Carbonates: Reagents For The Synthesis Of Carbamates And Protection Of Amino Groups 作者:Gérard Barcelo,Jean-Pierre Senet,Gérard Sennyey,Jean Bensoam,Albert Loffet 摘要:The Synthesis Of 1-Chloroalkyl Carbonates And Their Reaction With Various Type Of Amines Are Described. This Reaction Is Useful For The Synthesis Of Carbamate Pesticides And For The Protection Of Various Amino Groups, Including Amino Acids.
合成参考文献
参考文献:10.1007/s12010-012-0056-3 摘要:Sudar M, Valinger D, Findrik Z, Vasić-Rački Đ, Kurtanjek Ž. Effect of Different Variables on the Efficiency of the Baker's Yeast Cell Disruption Process to Obtain Alcohol Dehydrogenase Activity. Applied Biochemistry and Biotechnology. 2013 Jan 09;169(3):1039–55. doi: 10.1007/s12010-012-0056-3.