CAS: 73960-07-3; 4-(Difluoromethoxy)Benzaldehyde

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CAS号75-45-6 一氯二氟甲烷 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号115262-01-6 (溴二氟甲基)三甲基硅烷 | CAS号103962-07-8 3-[4-(difluorom... | CAS号84761-71-7 2,6-Dimethyl-3,...

4-甲酰基苯硼酸置于双氧水,Potassium Hydroxide体系中,用 水,乙腈 作为反应溶剂,化学反应 0.28H,以58%的收率获得产物4-(二氟甲氧基)苯甲醛
参考文献: Synthesis Of Difluoromethyl Ethers And Sulfides[fr] Synthèse De Difluorométhyléthers Et De Difluorométhylsulfures
标题: Synthesis Of Difluoromethyl Ethers And Sulfides[fr] Synthèse De Difluorométhyléthers Et De Difluorométhylsulfures
摘要:描述了使用一种简单,无臭氧破坏剂的方法合成二氟甲基醚和硫醚.使用这种试剂对酚进行二氟甲基化反应在室温下几分钟内就能完成,并且具有异常的官能团容忍性.温和的条件使得可能进行串联过程,将芳基硼酸,芳基卤代烃和芳烃转化为二氟甲基醚.机理研究支持一个涉及酚酚根攻击二氟卡宾的反应途径.

专利信息

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:WO-2014107380-A1
优先权日:2013-01-01
标 题 :Synthesis of difluoromethyl ethers and sulfides