CAS: 7314-65-0; 4-Methoxy-2-Methylpyrimidine

该化合物是一种环环有机化合物,在4级由甲氧基组替代,在2级由甲氧基组替代,这种结构具有独特的回动性和多功能性,使其成为制药和农用化学合成中有价值的中间体.其电子富含丙酰胺环有利于核生殖替代反应,而甲氧基和甲基组则增强溶性与稳定性.该化合物在生产活性药物成分和特殊化学品方面特别有用.高纯度可用于达到严格的工业标准,确保研究和工业应用的一贯性能.

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CAS号4994-86-9 4-氯-2-甲基嘧啶 | CAS号186581-53-3 重氮甲烷 | CAS号19875-04-8 2-甲基-4-羟基嘧啶 | CAS号87273-20-9 (9CI)-2-(氯甲基)-4...

合成工艺路线路线简述

    📜4-氯-2-甲基嘧啶置于sodium体系中,用 甲醇,水 作为反应溶剂,化学反应生成 4-甲氧基-2-甲基嘧啶
    参考文献:Substituted Thienoimidazole Derivatives,A Process For The Preparation
    标题:Substituted Thienoimidazole Derivatives,A Process For The Preparation
    摘要:取代噻唑咪唑衍生物,其制备方法,含有它们的药物组合物,以及将其用作胃酸分泌抑制剂,胃粘膜保护剂和治疗肠道炎症的药物的用途.该发明涉及以下式的化合物:其中a代表t表示-S-,-So-或-So2-,R1至r10,X,Y和z的含义如描述中所示,以及其制备方法,含有它们的药物组合物,以及将其用作胃酸分泌抑制剂,胃粘膜保护剂和治疗肠道炎症的用途.

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    专利信息


    专利号:US-9676783-B2
    优先权日:2008-10-22
    标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
    权利人:ARRAY BIOPHARMA INC
    摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

    专利号:WO-2023091726-A1
    优先权日:2021-11-18
    标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
    发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
    权利人:SYROS PHARMACEUTICALS INC
    摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

    专利号:KR-20160058757-A
    优先权日:2013-07-17
    标题 :Azaindole compounds, synthesis thereof, and methods of using the same

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    合成参考文献


    摘要:S. Mizukami and E. Hirai. J. Org. Chem. 31, 1199 (1966).
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