CAS: 6834-98-6; (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-Nonahydroxy-3-[(1R)-1-Hydroxyhexyl]-17,28-Dimethyl-1-Oxacyclooctacosa-17,19,21,23,25-Pentaen-2-One

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非律平 15-Deoxylagosin 480-49-9

📜非律平置于ferredoxin Reductase,Ferredoxin,Ptnj (Dv517_01420) Gene From Streptomyces Sp. S816,氧气,还原型辅酶ii(Nadph)四钠盐体系中,化学反应 3.0H,反应生成 喷他霉素
参考文献:菲律宾链霉菌属中的戊霉素生物合成.s816:细胞色素p450催化的c-14羟基基团的安装.
标题:菲律宾链霉菌属中的戊霉素生物合成.s816:细胞色素p450催化的c-14羟基基团的安装.
摘要:戊霉素是一种多烯抗生素,已在瑞士注册用于治疗阴道念珠菌病,滴虫和混合感染.化学不稳定性阻碍了其作为药物的广泛应用和开发.在这里,我们报告鉴定链霉菌.s816,从菲律宾红树林土壤中分离出来,作为喷霉素的生产者.基因组序列分析确定了推测的喷他霉素生物合成基因簇,该基因簇与负责菲律宾iii生物合成的基因簇高度相似.菲律宾蛋白iii生物合成基因簇中不存在的ptnj基因显示出编码能够将菲律宾蛋白iii转化为戊霉素的细胞色素p450.这证实了簇指导喷他霉素的生物合成,为生产戊霉素类似物的生物合成工程方法铺平了道路.发现其他几个链霉菌基因组包含ptnj直向同源物,这些直向同源物与编码聚酮化合物合酶的基因簇集,这些基因的结构与负责菲林iii和戊霉素的组装相似,这表明戊霉素在链霉菌种中可能很常见.
DOI:10.1021/acschembio.9B00270

专利信息

专利号:US-9889182-B2
优先权日:2009-09-15
标 题 :Assisted enzyme replacement therapy
发明人：ESKO JEFFREY D; TOR YITZHAK
权利人:ESKO JEFFREY D; TOR YITZHAK; UNIV CALIFORNIA
摘要:Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.

专利号:EP-0635577-B1
优先权日:1993-07-23
标 题 :Screen for inhibitors of melanin biosynthesis
发明人：BRINDLE FRANCES HARRIET ELIZAB; FROELIGER EUNICE HARRIET
权利人:BASF AG
摘要:A method for the identification of agents that inhibit melanin biosynthesis involves the incubation of test samples in cultures of a fungus that produces melanin. Observation of altered pigmentation in the culture or culture area containing test sample indicates inhibition of melanin biosynthesis. Preferred cultures for the screen contain a fungus that pigments in the light or the dark such as Cladosporium cucumerinum. Preferred embodiments employ test samples on disks or in wells in solidified cultures and a known melanin synthesis inhibitor as a positive control which is compared to the test sample by simple visual inspection.

专利号:US-7199128-B2
优先权日:2005-02-02
标题 :8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
发明人：BRADBURY BARTON J; WILES JASON ALLAN; DESHPANDE MILIND; WANG QIUPING; HASHIMOTO AKIHIRO; LUCIEN EDLAINE
权利人:ACHILLION PHARMACEUTICALS INC
摘要:The invention provides compounds and salts of Formula I and Formula II: n nwhich possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A 1 , A 8 , R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 are defined herein.n n Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.