麦角固醇置于sodium,N-甲基苯胺体系中,化学反应生成 双氢速甾醇 参考文献:Westerhof; Buisman,Recueil Des Travaux Chimiques Des Pays-Bas,1956,Vol. 75,P. 453,461 标题:Westerhof; Buisman,Recueil Des Travaux Chimiques Des Pays-Bas,1956,Vol. 75,P. 453,461
专利号:US-7339065-B2 优先权日:2003-07-21 标题 :Design and synthesis of optimized ligands for PPAR 发明人:AVERY MITCHELL A; PERSHADSINGH HARRIHAR A 权利人:BETHESDA PHARMACEUTICALS INC; UNIV MISSISSIPPI 摘要:This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.
专利号:US-11640525-B2 优先权日:2018-07-23 标 题:Synthesis of sequential, spectral, and time-series data 发明人:MISRA SIDDHARTH; HE JIABO 权利人:UNIV OKLAHOMA 摘要:A method comprises performing data pre-processing of initial signals to obtain pre-processed initial signals; building a first machine learning model based on the pre-processed initial signals; generating output signals using the first machine learning model; computing ranks of the output signals; computing classifications of the output signals; and building a set of stacked machine learning models based on the ranks and the classifications. The set of stacked machine learning models may be used to generate subsurface well log data, NMR data, or other data.
专利号:US-9987208-B2 优先权日:2013-04-04 标题 :Elastin synthesis/regeneration promoting agent 发明人:NISHIZAKI TOMOYUKI; TANAKA AKITO 权利人:NISHIZAKI BIOINFORMATION RES INSTITUTE 摘要:8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.
专利号:WO-2025217452-A1 优先权日:2024-04-11 标 题 :Constrained ionizable cationic lipids and lipid nanoparticles 发明人:KARMALI PRIYA; TANIS STEVEN 权利人:CAPSTAN THERAPEUTICS INC 摘要:Ionizable cationic lipids, methods for synthesizing the same, intermediates useful in synthesis of the ionizable cationic lipids, and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for delivering nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNPs comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNPs (tLNPs), that is, LNPs in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNPs to a desired tissue or cell type.
专利号:US-2012172336-A2 优先权日:2009-03-19 标 题:Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations 发明人:GONNISSEN YVES; VOORSPOELS JODY 权利人:GONNISSEN YVES; VOORSPOELS JODY; SEPS PHARMA N V 摘要:The invention relates to a compound of formula (1) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R 1 to R 2 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.
专利号:CN-102884037-A 优先权日:2010-03-09 标题 :Synthesis of α-tocopherol derivatives, and methods of use thereof
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合成参考文献
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