CAS: 67-96-9; Dihydrotachysterol

该化合物是维生素D2的合成衍生物,专门设计用于显示类似的生物活动,其特点是它能够加强肠胃中的钙吸收,促进骨矿化,使其在治疗骨质瘤和等条件下有用;该化合物是一种脂肪溶解的维生素,这意味着它在脂质中溶解,并可以储存在体脂肪中;二氢裂痕酯醇通常以其活性形式施用,因为它在体内进行代谢转化以产生其作用;其化学结构包括一系列碳环和氢氧基组,有助于其生物活动;该物质一般被很好地调用,但与其他维生素D模拟剂一样,如果服用过量,可导致高血压.与任何药物一样,在医疗监督下使用二氢裂痕酯醇对可能的副作用进行监测并确保适当施用.

结构式图片

欧盟法规

ECHA物质ECHA物质化妆品禁用物质清单C&L通报REACH预注册

上下游产品

Calciferol R)-3ar-Methyl-3c-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-7-[2-((2S)-5t-hydroxy-2r-methyl-cyclohexyliden-(seqcis))-aethyliden-(seqtrans)]-(7atH)-hexahydro-indan(3aR)-3ar-Methyl-3c-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-7-[2-((2S)-5t-hydroxy-2r-methyl-cyclohexyliden-(seqcis))-aethyliden-(seqtrans)]-(7atH)-hexahydro-indan tachysterol 2 Rtoxisterol2 RS,5E,7E,10S)-3-acetoxy-9,10-seco-ergosta-5,7,22t-triene(3S,5E,7E,10S)-3-acetoxy-9,10-seco-ergosta-5,7,22t-triene E,10S)-9,10-seco-ergosta-4,7,22t-trien-3-one(7E,10S)-9,10-seco-ergosta-4,7,22t-trien-3-one S:10S)-9.10-seco-ergostatrien-(5t.7c.22t)-yl-(3)-ester)3.5-dinitro-benzoic acid-((3S:10S)-9.10-seco-ergostatrien-(5t.7c.22t)-yl-(3)-ester)

合成工艺路线路线简述

    麦角固醇置于sodium,N-甲基苯胺体系中,化学反应生成 双氢速甾醇
    参考文献:Westerhof; Buisman,Recueil Des Travaux Chimiques Des Pays-Bas,1956,Vol. 75,P. 453,461
    标题:Westerhof; Buisman,Recueil Des Travaux Chimiques Des Pays-Bas,1956,Vol. 75,P. 453,461

    海关参考信息

    专利信息


    专利号:US-7339065-B2
    优先权日:2003-07-21
    标题 :Design and synthesis of optimized ligands for PPAR
    发明人:AVERY MITCHELL A; PERSHADSINGH HARRIHAR A
    权利人:BETHESDA PHARMACEUTICALS INC; UNIV MISSISSIPPI
    摘要:This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

    专利号:US-11640525-B2
    优先权日:2018-07-23
    标 题:Synthesis of sequential, spectral, and time-series data
    发明人:MISRA SIDDHARTH; HE JIABO
    权利人:UNIV OKLAHOMA
    摘要:A method comprises performing data pre-processing of initial signals to obtain pre-processed initial signals; building a first machine learning model based on the pre-processed initial signals; generating output signals using the first machine learning model; computing ranks of the output signals; computing classifications of the output signals; and building a set of stacked machine learning models based on the ranks and the classifications. The set of stacked machine learning models may be used to generate subsurface well log data, NMR data, or other data.

    专利号:US-9987208-B2
    优先权日:2013-04-04
    标题 :Elastin synthesis/regeneration promoting agent
    发明人:NISHIZAKI TOMOYUKI; TANAKA AKITO
    权利人:NISHIZAKI BIOINFORMATION RES INSTITUTE
    摘要:8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.

    专利号:WO-2025217452-A1
    优先权日:2024-04-11
    标 题 :Constrained ionizable cationic lipids and lipid nanoparticles
    发明人:KARMALI PRIYA; TANIS STEVEN
    权利人:CAPSTAN THERAPEUTICS INC
    摘要:Ionizable cationic lipids, methods for synthesizing the same, intermediates useful in synthesis of the ionizable cationic lipids, and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for delivering nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNPs comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNPs (tLNPs), that is, LNPs in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNPs to a desired tissue or cell type.

    专利号:US-2012172336-A2
    优先权日:2009-03-19
    标 题:Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations
    发明人:GONNISSEN YVES; VOORSPOELS JODY
    权利人:GONNISSEN YVES; VOORSPOELS JODY; SEPS PHARMA N V
    摘要:The invention relates to a compound of formula (1) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R 1 to R 2 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.

    专利号:CN-102884037-A
    优先权日:2010-03-09
    标题 :Synthesis of α-tocopherol derivatives, and methods of use thereof
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    主要参考文献


    1: Voigts AL, Felsenfeld AJ, Llach F. The effects of calciferol and its metabolites on patients with chronic renal failure. I. Calciferol, dihydrotachysterol, and calcifediol. Arch Intern Med. 1983 May;143(5):960-3. Review. Review. Review. German. Review. Italian. Review. Review. Review. Review. German. Review.
    10: Varga E. [Treatment of hypoparathyroidism]. Orv Hetil. 2005 May 15;146(20):1019-20. Review. Hungarian. Review. Review.
    13: Anast CS. Parathyroid disorders in children. Pediatr Ann. 1980 Oct;9(10):376-83. Review. Review.

    合成参考文献


    摘要:Drugs in Japan, 6(330), 1982
    摘要:Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 2967
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
    摘要:Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1585
    摘要:Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1582
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