CAS: 627-03-2; 2-Ethoxyacetic Acid

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817-95-8 62957-60-2 110-99-6

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CAS号64-17-5 乙醇 | CAS号79-11-8 氯乙酸 | CAS号79-08-3 溴乙酸 | CAS号51770-98-0 2-ethoxyacetamide | CAS号110-80-5 乙二醇乙醚 | CAS号124-38-9 二氧化碳 | CAS号4279-03-2 magnesium,metha... | CAS号201230-82-2 carbon monoxide | CAS号122-51-0 原甲酸三乙酯 | CAS号3188-13-4 氯甲基乙醚 | CAS号50-00-0 甲醛 | CAS号462-95-3 二乙氧基甲烷 | CAS号64-17-5 乙醇 | CAS号817-95-8 乙氧基乙酸乙酯 | CAS号79-14-1 羟基乙酸 | CAS号31059-08-2 1-imidazol-1-yl... | CAS号75-03-6 碘乙烷 | CAS号14077-58-8 乙氧基乙酰氯 | CAS号17640-26-5 methyl 2-ethoxy... | CAS号7565-74-4 tributylstannyl...

2-乙氧基乙酸乙酯置于lithium Hydroxide Monohydrate,水体系中,用 四氢呋喃 作为反应溶剂,化学反应 12.0H,以5%的收率获得产物乙氧基乙酸
参考文献: N-(3-(2-(4-Chlorophenoxy)Acetamido)Bicyclo[1.1.1]Pentan-1-yl)-2-Cyclobutane-1-Carboxamide Derivatives And Related Compounds As Atf4 Inhibitors For Treating Cancer And Other Diseases[fr] Dérivés De N-(3-(2-(4-Chlorophénoxy)Acétamido)Bicyclo[1.1.1]Pentan-1-yl)-2-Cyclobutane-1-Carboxamide Et Composés Apparentés En Tant Qu'Inhibiteurs Atf4 Pour Le Traitement Du Cancer Et D'Autres Maladies
标题: N-(3-(2-(4-Chlorophenoxy)Acetamido)Bicyclo[1.1.1]Pentan-1-yl)-2-Cyclobutane-1-Carboxamide Derivatives And Related Compounds As Atf4 Inhibitors For Treating Cancer And Other Diseases[fr] Dérivés De N-(3-(2-(4-Chlorophénoxy)Acétamido)Bicyclo[1.1.1]Pentan-1-yl)-2-Cyclobutane-1-Carboxamide Et Composés Apparentés En Tant Qu'Inhibiteurs Atf4 Pour Le Traitement Du Cancer Et D'Autres Maladies
摘要:该发明涉及替代的桥接环戊烷衍生物.具体而言,该发明涉及根据式(i)的化合物,其中x,A,B,C,D,L2,L3,Y1,Y2,R2,R4,R5,R6,Z2,Z4,Z5和z6如本文所定义,并其盐.该发明还涉及包含该发明化合物的药物组合物.该发明还涉及用于抑制atf4(激活转录因子4)途径和治疗相关疾病的方法的化合物,例如癌症,神经退行性疾病和许多其他疾病,使用该发明化合物或包含该发明化合物的药物组合物.该发明的优选化合物是n-(3-(2-(4-氯苯氧基)乙酰氨基)双环[1.1.1]戊烷-1-基)-2-环丁烷-1-羧酰胺衍生物及相关化合物.

专利信息

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-7423169-B2
优先权日:2001-06-11
标 题:Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
发明人：RAILLARD STEPHEN P; ZHOU CINDY X; YAO FENMEI; MANTHATI SURESH KUMAR; XIANG JIA-NING; GALLOP MARK A
权利人:XENOPORT INC
摘要:The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.

专利号:US-6166237-A
优先权日:1999-08-13
标题:Removal of dissolved silicates from alcohol-silicon direct synthesis solvents
发明人：SIMANDAN TIBERIU LADISLAU; MENDICINO FRANK D
权利人:CROMPTON CORP
摘要:Dissolved silanes, silicones and silicates from solvents used in the slurry phase Direct Synthesis of alkoxysilanes are removed by adding a compatabilizing agent and water to generate filterable precipitates and reusable solvent. The solvents are thereby remediated and made suitable for reuse in Direct Synthesis processes. Foaming is reduced with the remediated solvent and silicon conversion rates are higher. The precipitates are easily filtered and retain negligible quantities of solvent.

专利号:US-6090965-A
优先权日:1998-04-02
标题:Removal of dissolved silicates from alcohol-silicon direct synthesis solvents
发明人：LEWIS KENRICK MARTIN; YU HUA; ENG REGINA N
权利人:OSI SPECIALTIES INC
摘要:Dissolved silanes, silicones and silicates from solvents used in the slurry phase Direct Synthesis of alkoxysilanes are removed by adding a carboxylic acid such as formic acid to generate filterable precipitates and reusable solvent. The solvents are thereby remediated and made suitable for reuse in Direct Synthesis processes. Foaming is reduced with the remediated solvent and silicon conversion rates are higher. The precipitates are easily filtered and retain negligible quantities of solvent.

专利号:US-2024199680-A1
优先权日:2021-04-02
标 题:Synthesis of fluorinated cyclic dinucleotides
发明人：AN CHIHUI; FIER PATRICK S; HIRAGA KAORI; LIU ZHIJIAN; MARSHALL NICHOLAS M; MCINTOSH JOHN; MILLER STEVEN P; MOORE JEFFREY C; MURPHY GRANT S; OBLIGACION JENNIFER V; PAN WEILAN; PENG FENG; SALEHI MARZIJARANI NASTARAN; WINSTON MATTHEW S
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2′-deoxy-2′-fluoro-5′-O—[(R)-hydroxymercaptophosphinyl]-P-thio-β-D-arabino-adenylyl-(3′→5′)-3′-deoxy-3′-fluoroguanosine cyclic nucleotide, which is also known as (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2, 10-bis(sulfanyl)octahydro-2H,10H, 12H-2λ 5 ,10λ 5 -5,8-methanofuro[3,2-1][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.