CAS: 62373-80-2; 3-(4-Methoxyphenoxy)Benzaldehyde

上下游产品

4-methoxyphenylboronic acid meta-hydroxybenzaldehyde 4-chloromethoxybenzene 3-Formylphenylboronic acid 3-(4-methoxyphenoxy)benzoic acid 1-[3-(4-Methoxyphenoxy)-phenyl]-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one 3-(4'-methoxy-phenoxy) alpha-cyano benzyl alcohol N-(2,2-dimethoxyethyl)-3-(4-methoxyphenoxy)benzylamine hydr°Chloride

📜2-(3-溴苯基)-1,3-二恶烷置于盐酸,Copper(L) Iodide,N,N-二甲基甘氨酸盐酸盐,Caesium Carbonate体系中,用 四氢呋喃,1,4-二氧六环,水 作为反应溶剂,化学反应 24.0H,反应生成 3-(4-甲氧基苯氧基)苯甲醛
参考文献:非核苷结核分枝杆菌胸苷酸激酶抑制剂的结构辅助优化
标题:非核苷结核分枝杆菌胸苷酸激酶抑制剂的结构辅助优化
摘要:结核分枝杆菌胸苷酸激酶 (Mt Tmpk) 已成为合理药物设计的一个有吸引力的靶标.我们最近研究了新的非核苷mt Tmpk 抑制剂家族,努力使mt Tmpk 抑制剂化学空间多样化.我们在这里报告了一系列新的mt Tmpk 抑制剂,通过将 Topliss 方案与合理的药物设计方法相结合,由mt Tmpk的两种共晶结构与已开发的抑制剂复合物推动.这些努力在我们的测定中提供了最有效的mt Tmpk 抑制剂,其中两种类似物对 H37Rv Mtb 显示出低微摩尔 Mic 值.制备的抑制剂针对mt Tmpk 核苷酸结合袋中的新亚位点,从而为其成药性提供新的见解.我们研究了外排泵的作用以及细胞壁透化剂对选定化合物的影响,以潜在地解释有效的酶抑制和全细胞活性之间缺乏相关性.
DOI:10.1016/j.Ejmech.2021.113784

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-6187923-B1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones
发明人：DENER JEFFREY MARK; LY CUONG QUOC
权利人:AXYS ADVANCED TECHNOLOGIES INC
摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:

专利号:US-6045755-A
优先权日:1997-03-10
标题 :Apparatus and method for combinatorial chemistry synthesis
发明人：LEBL MICHAEL; POKORNY VIT; KRCHNAK VIKTOR
权利人:TREGA BIOSCIENCES INC
摘要:In a first embodiment, this invention includes an integrated robot apparatus for performing combinatorial chemistry synthesis protocols and having interchangeable work-stations, robot arm tools, and reaction vessels and reaction vessel arrays. The work-stations and tools are specialized to perform tasks necessary for the synthesis in a plurality of the reaction vessels grouped in a plurality of the reaction vessel arrays. Preferably, these elements function interchangeably because they have standardized sizes and conformation. The work-stations and tools include those for fluid dispensing or aspirating from individual reaction vessels or from all the reaction vessels in an array simultaneously. The reaction vessels can include, alternatively, stackable, ball-sealed reaction vessels, microtitre-like reaction vessel arrays, arrays of independent reaction vessels, valve-sealed reaction vessels, septum-sealed reaction vessels, and syringe reaction vessels. In alternative embodiments, this invention includes these work-stations, tools, reaction vessels and reaction vessel arrays in various combinations or sub-combinations either for use in partially integrated robots or for manual or standalone use.

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries