CAS: 6211-16-1; (S)-2,5-Diaminopentanoic Acid Dihydrochloride

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专利信息

专利号:US-4234744-A
优先权日:1978-12-18
标 题 :Process for the production of aminoacid hydrochlorides/or diaminoacid dihydrochlorides
发明人：EFFENBERGER FRANZ; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:Aminoacid hydrochlorides or diaminoacid dihydrochlorides are produced by first reacting a halocarboxylic acid ester with an alkali metal cyanate in the presence of an alcohol to form the corresponding mono- or diurethane and then saponifying this to the corresponding mono- or dihydrochloride. The new process is relatively versatile in its use and above all opens up an elegant synthesis route for lysine.

专利号:US-6949679-B1
优先权日:1998-04-21
标 题 :Polyamine transport inhibitors
发明人：POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREAULT RENE
权利人:UNIV LAVAL
摘要:The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene.