专利号:US-6262251-B1 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
专利号:WO-9847910-A1 优先权日:1997-04-21 标题:Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-5874532-A 优先权日:1997-01-08 标 题 :Method for solution phase synthesis of oligonucleotides and peptides 发明人:PIEKEN WOLFGANG; GOLD LARRY 权利人:NEXSTAR PHARMACEUTICALS INC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-6001966-A 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides and peptides 发明人:PIEKEN WOLFGANG; GOLD LARRY 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:WO-9830578-A1 优先权日:1997-01-08 标题:Method for solution phase synthesis of oligonucleotides and peptides
专利号:CN-118489008-A 优先权日:2021-12-23 标题:Scalable and high purity cell-free synthesis of closed-end DNA vectors
参考文献:10.1007/s12274-022-4793-5 摘要:Zhang L, Chu M, Ji C, Tan J, Yuan Q. Preparation, applications, and challenges of functional DNA nanomaterials. Nano Res. 2022 Aug 31;16(3):3895–912. doi: 10.1007/s12274-022-4793-5.