专利号:US-11833132-B1 优先权日:2023-06-26 标 题 :Method of synthesis of a nanocomposite including silymarin-loaded collagen nanoparticles 发明人:ALI MAI MOSTAFA KHALAF; AHMED HANY MOHAMED ABD EL-LATEEF; MOHAMMED AHMED MOHAMMED ABU-DIEF; SHAHEEN HAZEM MOHAMED; BATIHA GABER ELSABER ABD EL-WANIS; SHALABY MANAL ALY; ALAMH AMANY MABROUK ABD ELHADY 权利人:UNIV KING FAISAL 摘要:A method of synthesizing silymarin-loaded collagen collagen nanoparticles can include dissolving silymarin in an alcohol to provide a solution, mixing the solution with acetic acid to provide an acetic acid mixture, and adding the glutaraldehyde to the mixture to provide silymarin nanoparticles. The silymarin nanoparticles can be dissolved in a further alcohol and mixed for a period of time to provide a silymarin nanoparticle mixture. Then, the silymarin nanoparticles can be mixed with collagen nanoparticles to provide a silymarin/collagen mixture. Glutaraldehyde can be added to the collagen mixture to provide the nanocomposite formulation.
专利号:US-6153615-A 优先权日:1991-12-26 标 题 :Blocking induction of tetrahydrobioterin to block induction of nitric oxide synthesis 发明人:GROSS STEVEN S 权利人:CORNELL RES FOUNDATION INC 摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonists are administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylactic or curative effect for endotoxin- or cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension). The tetrahydrobiopterin synthesis antagonist may be administered with α 1 -adrenergic agonist or with nitric oxide synthase inhibitor. The tetrahydrobiopterin synthesis antagonists are also administered to attenuate inflammation caused by induced nitric oxide production in immune cells. Unwanted counterproductive or side effects can be eliminated or ameliorated by administration additionally of levodopa with or without carbidopa and L-5-hydroxytryptophane.
专利号:US-6274581-B1 优先权日:1991-12-26 标 题 :Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis 发明人:GROSS STEVEN S 权利人:CORNELL RES FOUNDATION INC 摘要:Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonist are administered to inhibit nitric oxide synthesis from arginine in vascular smooth muscle cells in a subject in need of such inhibition (e.g. for prophylactic or curative effect for cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension).
专利号:US-12012375-B2 优先权日:2018-05-17 标 题:Prostaglandin F2 alpha derivatives for decreasing intraocular pressure 发明人:BEZUGLOV VLADIMIR VILENOVICH; SERKOV IGOR VIKTOROVICH; Lyubimov Igor Ivanovich; GRETSKAYA NATALIYA MIKHAILOVNA 权利人:GURUS BIOPHARM LLC 摘要:The invention relates to clinical chemistry, in particular, to new biologically active compounds—amide derivatives of prostaglandin F2α. These compounds have low cytotoxicity and are capable of stimulating formation of endogenous nitrogen oxide in mammal cells. Synthesis of such compounds promotes expansion of nomenclature of biologically active derivatives of prostaglandin F2α capable of reducing intraocular pressure.
专利号:US-8323929-B2 优先权日:1999-06-17 标题 :Methods for detecting nucleic acid sequence variations 发明人:WANG SHA-SHA; THORNTON KEITH; NADEAU JAMES G; HELLYER TOBIN J 权利人:WANG SHA-SHA; THORNTON KEITH; NADEAU JAMES G; HELLYER TOBIN J; BECTON DICKINSON CO 摘要:The invention employs an unlabeled signal primer comprising a 5′ adapter sequence for detection of variations in nucleic acid target sequences. The detection system further comprises a reporter probe, the 3′ end of which hybridizes to the complement of the 5′ adapter sequence of the signal primer to produce a 5′ overhang. Polymerase is used to fill in the overhang and synthesize the complement of the 5′ overhang of the reporter probe. Synthesis of the reporter probe complement is detected, either directly or indirectly, as an indication of the presence of the target.
专利号:WO-2024219698-A1 优先权日:2023-04-19 标 题 :Composition for preventing, ameliorating, or treating arthritis, containing potentilla chinensis extract or apigenin-7-o-glucuronide as active ingredient 发明人:JUNG BYUNG CHAN; LEE SUN HEE; LEE KYUNG-TAE; LEE SANG OK; SHIN DONG MIN 权利人:BELABELBIO INC 摘要:The present invention discloses a composition for preventing, ameliorating, or treating arthritis, the composition containing a Potentilla chinensis extract or apigenin-7-O-glucuronide as an active ingredient. The present invention inhibits the expression of MMP-1 and MMP-9, increases the synthesis of procollagen type 2, and not only alleviates inflammation but also inhibits inflammatory pain, and thus has the effect of preventing, ameliorating, or treating arthritis.
参考文献:10.1186/1471-2261-11-43 摘要:Ajmani P, Yadav HN, Singh M, Sharma PL. Possible involvement of caveolin in attenuation of cardioprotective effect of ischemic preconditioning in diabetic rat heart. BMC Cardiovascular Disorders. 2011 Jul 12;11(1):43. doi: 10.1186/1471-2261-11-43. 参考文献:10.1155/2011/385780 摘要:Burnett BP, Bitto A, Altavilla D, Squadrito F, Levy RM, Pillai L. Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant. Mediators Inflamm. 2011;2011():385780. 参考文献:10.1186/1748-717x-6-86 摘要:He Z, Zhang H, Yang C, Zhou Y, Zhou Y, Han G, Xia L, Ouyang W, Zhou F, Zhou Y, Xie C. The interaction between different types of activated RAW 264.7 cells and macrophage inflammatory protein-1 alpha. Radiation Oncology. 2011 Jul 22;6(1):86. doi: 10.1186/1748-717x-6-86.