CAS: 52589-11-4; Phellamurin
该化合物是一种主要来自草药传统使用的植物Phellodendron amurense树皮的裂变质化合物,它显示出显著的生物活动,包括抗氧化剂,抗炎和潜在的抗癌特性.在结构上,它与其他氟化物有相似之处,它具有二氢氟化物脊椎,它有助于它研究自由基质和调节细胞信号路径的能力.研究表明,Phellamurin 可能会通过诱导流行性疾病和抑制血管产生抑制肿瘤生长.它中度溶液在极地溶剂中的溶性使其适合进行药理学研究.目前正在进一步调查,以探索其机制和治疗应用,特别是在与氧化性压力有关的紊乱和肿瘤学方面.
- 英文名称Phellamurin
- 中文名称(二氢)黄柏甙
- IUPAC名称Phellamurin
- 其它别名Phellamurin; (2R)-7-(β-D-Glucopyranosyloxy)-2,3-Dihydro-3β,5-Dihydroxy-2α-(4-Hydroxyphenyl)-8-(3-Methyl-2-Butenyl)-4H-1-Benzopyran-4-One; (Dihydro) Phellodendron; 4H-1-Benzopyran-4-One,7-(B-D-Glucopyranosyloxy)-2,3-Dihydro-3,5-Dihydroxy-2-(4-Hydroxyphenyl)-8-(3-Methyl-2-Buten-1-yl)-,(2R,3R)-; 4H-1-Benzopyran-4-One, 7-(β-D-Glucopyranosyloxy)-2,3-Dihydro-3,5-Dihydroxy-2-(4-Hydroxyphenyl)-8-(3-Methyl-2-Buten-1-yl)-, (2R,3R)-; (2R,3R)-3,5-Dihydroxy-2-(4-Hydroxyphenyl)-8-(3-Methylbut-2-Enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-2,3-Dihydrochromen-4-One; Phellamurin, 10 Mm In Dmso
- CAS编号52589-11-4
- MFCD编号:MFCD00869630
- FDA UNII编号:UXB86HY2NK
- 分子式:C26H30O11分子量:518.52
- 产品CID: 2509520
- 产品分类天然产物 → 黄酮类化合物
物理性质
- 沸点861.5±65.0 °C(预测)
- 闪点290.7 °C
- 密度1.504±0.06 g/cm3(预测)
- pKa:7.15±0.60(预测)
- PSA:186.37
- LogP:0.4625
- 折射率1.671
- 蒸汽压1.2E-31 mmHg at 25 °C
- 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
- 外观形态淡黄色至黄色粉末
- 储存条件-20°C
- 产品应用该化合物是一种与* PHELLODENDRON AMURENSE* 叶叶叶分离的裂变胶片,具有多种生物活动,抑制肠道P-GP/ABCB1/MDR1, 从而有可能逆转多种药物的抗药性;诱发人类中毒;通过抑制体内骨质瘤生长而表现出抗沙素活动;抑制PI3K/AKT/MTOR信号路径,这表现在体内(U2OS和SAOS-2细胞)和体外色素模型中P-PP3P3KK/PI-3K,P-AK T/AKOT和P-MTOR/MTOR的比率下降;以及作为对燕尾蝴蝶蝴蝶的电磁阻力.
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2902600000-乙苯
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专利信息
专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
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合成参考文献
参考文献:10.1186/s12870-021-03132-0
摘要:Dossou SSK, Xu F, Cui X, Sheng C, Zhou R, You J, Tozo K, Wang L. Comparative metabolomics analysis of different sesame (Sesamum indicum L.) tissues reveals a tissue-specific accumulation of metabolites. BMC Plant Biology. 2021 Jul 24;21(1):352. doi: 10.1186/s12870-021-03132-0.
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