CAS: 517-09-9; Equilenin

相似化合物

566-76-7 3131-23-5 4011-48-7

上下游产品

CAS号3907-67-3 3-Methoxyestra-... | CAS号2526-84-3 3,17α,21-Trihyd... | CAS号2752-08-1 1,3,5(10),6,8-1... | CAS号6030-91-7 Equilenin acetate | CAS号474-86-2 马烯雌酮 | CAS号43085-97-8 3-hydroxyestra-... | CAS号1423-97-8 17β-二氢马鞭草素 | CAS号434-22-0 诺龙 | CAS号53-16-7 雌酚酮 | CAS号170473-80-0 (13S,14S)-13-me... | CAS号16680-48-1 1,3,5(10), 6,8-...

📜诺龙置于2,3,5-三甲基吡啶,Selenium(Iv) Oxide,对甲苯磺酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 马萘雌酮
参考文献:Corbellini; Gerali; Ferrara,Farmaco,Edizione Scientifica,1964,Vol. 19,P. 913-922
标题:Corbellini; Gerali; Ferrara,Farmaco,Edizione Scientifica,1964,Vol. 19,P. 913-922

专利信息

专利号:US-3933870-A
优先权日:1973-07-02
标 题 :Synthesis of A-ring aromatic steroids
发明人：COHEN NOAL
权利人:HOFFMANN LA ROCHE
摘要:Total synthesis of steroids of the estrone and equilenin series involving conjugate 1,4-addition of a meta-substituted benzyl organometallic reagent to a C/D bicyclic methylene ketone. An aromatization of the B-ring of Δ 9(11) estrone derivatives.

专利号:US-4092483-A
优先权日:1973-10-16
标题 :Intermediates for steroid total synthesis process utilizing asymmetric induction
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.

专利号:US-4102925-A
优先权日:1970-12-21
标题:Steroid total synthesis process utilizing asymmetric induction
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.

专利号:US-4011211-A
优先权日:1973-10-16
标题:Steroid total synthesis process utilizing asymmetric induction
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy aceto-phenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.

专利号:US-2013261317-A1
优先权日:2010-09-27
标题 :Methods for preparing synthetic bile acids and compositions comprising the same
发明人：MORIARTY ROBERT M; RAO PHOTON
权利人:MORIARTY ROBERT M; RAO PHOTON; KYTHERA BIOPHARMACEUTICALS INC
摘要:This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C 14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.

专利号:US-2003158432-A1
优先权日:2002-01-08
标 题:Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex