CAS: 474310-74-2; 2-(Pyridin-3-yl)Acetimidamide

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20173-24-4 307496-23-7 1185294-73-8

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CAS号6443-85-2 3-吡啶基乙腈

📜3-吡啶乙腈置于sodium Methylate,氯化铵体系中,用 甲醇 作为反应溶剂,化学反应 26.0H,以44%的收率获得产物2-(3-吡啶基)乙酰胺 2Hcl
参考文献:Homoazanicotine: A Structure-Affinity Study For Nicotinic Acetylcholine (Nach) Receptor Binding
标题:Homoazanicotine: A Structure-Affinity Study For Nicotinic Acetylcholine (Nach) Receptor Binding
摘要:We Have Recently Identified 3-[(1-Methyl)-4,5-Dihydro-1H-Imidazol-2-yl)Methyl]Pyridine (Homo-Azanicotine,8) As A Novel Nicotinic Acetylcholinergic (Nach) Receptor Ligand. In The Present Investigation,After We Determined That 8 Binds Selectively At Nicotinic (K-I = 7.8 Nm) Vs Muscarinic (K-I > 10 000 Nm) Acetylcholinergic Receptors,We Examined Its Structure-Affinity Relationships For Nach Receptor Binding. The Features Investigated Included The Influence Of (I) The Composition Of Connector That Separates The Two Rings,(II) The N-Methyl Group,(Iii) The Ring Opening Of The Imidazoline Ring,(Iv) The Pyridine Nitrogen Atom,And (V) The Aromatization Of The Imidazoline Ring On Nach Receptor Affinity. As With Nicotine,The Parent Structure Seems Optimal And Most Structural Changes Reduce Nach Receptor Affinity. Also,As With Nicotine Analogues,Alteration Of The Spacer Group Influences Affinity In A Manner That Is Somewhat Different Than That Seen With The Parent Structure.
DOI:10.1021/jm020188S