CAS: 4360-12-7; (5Ar,6S,8R,9S,10R,11R,11As,12Ar,13R)-9-Ethyl-5-Methyl-5A,6,8,9,10,11,11A,12-Octahydro-5H-6,10:11,12A-Dimethanoindolo[3,2-B]Quinolizine-8,13-Diol

该化合物是一种自然产生的藻类,主要产自Rauvolfia 蛇根植物(俗称印度蛇根),被归类为IA类抗心律激素,这意味着它用来通过稳定心膜膜和延长行动可能持续的时间来治疗某些类型的心律不齐,这表示它用来治疗某些类型的心律不齐,稳定心肌膜和延长行动可能持续的时间.Ajmaline有一个复杂的化学结构,其特点是一个包括氮原子在内的四环框架,有助于其药理特性.该物质展示了一系列生物活动,包括镇静剂和抗血压效应,并且已经研究过它可能用于心脏学以外的治疗用途.Ajmaline通常在临床环境中进行,其影响可能因剂量和个人患者因素而不同.与许多药理活性化合物一样,它必须监测潜在的副作用,包括低温和胸腔.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

(1R,4aS,7S,7aR)-nepetalactone diacetylajmaline R)-17,21α-dihydroxy-4-methyl-ajmalanium; iodide(17R)-17,21α-dihydroxy-4-methyl-ajmalanium; iodide β-propyl-ajmaline bitartrateNβ-propyl-ajmaline bitartrate R)-17,21α-dihydroxy-4-methyl-ajmalanium; hydroxide(17R)-17,21α-dihydroxy-4-methyl-ajmalanium; hydroxide

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:WO-2013087821-A1
    优先权日:2011-12-15
    标题:Overproduction of jasmonates in transgenic plants
    发明人:CHAMPION ANTONY
    权利人:INST RECH DEVELOPPEMENT IRD
    摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

    专利号:EP-3478664-B1
    优先权日:2016-07-04
    标题 :Methods for the synthesis of deuterated dextromethorphan

    专利号:CN-107417595-A
    优先权日:2017-03-27
    标题:A method for the synthesis of a series of monoterpene indole alkaloid skeletons and natural products based on free radical tandem reactions

    专利号:US-2019241525-A1
    优先权日:2016-07-04
    标题:Methods for the synthesis of deuterated dextromethorphan

    专利号:US-10865187-B2
    优先权日:2016-07-04
    标题 :Methods for the synthesis of deuterated dextromethorphan
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    主要参考文献


    1: Rizzo A, Borio G, Sieira J, Van Dooren S, Overeinder I, Bala G, Pappaert G, Maj R, Osório TG, Terasawa M, Galli A, Cecchini F, Miraglia V, Ströker E, La Meir M, Brugada P, Chierchia GB, de Asmundis C. Ajmaline Testing and the Brugada Syndrome. Am J Cardiol. 2020 Nov 15;135:91-98. doi: 10.1016/j.amjcard.2020.08.024. Epub 2020 Aug 27. 135(11):513-5. German. doi: 10.1055/s-0030-1249197. Epub 2010 Mar 10.
    55:1-87. doi: 10.1016/s0099-9598(01)55002-6. 31(7):153-5.
    19:1381-2. Polish. 10(10):e005775. doi: 10.1161/CIRCEP.117.005775.

    合成参考文献


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    摘要:American Heart Journal., 70(719), 1965 []
    摘要:Archives of Environmental Contamination and Toxicology., 12(355), 1983 []
    参考文献:10.1007/s00108-003-1134-y
    摘要:Hartung U, Trappe HJ, Weismüller P. [A 66-year old female patient with tachycardia and syncope]. Internist (Berl). 2004 Apr;45(4):461–5. doi: 10.1007/s00108-003-1134-y.
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