专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:WO-2013087821-A1 优先权日:2011-12-15 标题:Overproduction of jasmonates in transgenic plants 发明人:CHAMPION ANTONY 权利人:INST RECH DEVELOPPEMENT IRD 摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.
专利号:EP-3478664-B1 优先权日:2016-07-04 标题 :Methods for the synthesis of deuterated dextromethorphan
专利号:CN-107417595-A 优先权日:2017-03-27 标题:A method for the synthesis of a series of monoterpene indole alkaloid skeletons and natural products based on free radical tandem reactions
专利号:US-2019241525-A1 优先权日:2016-07-04 标题:Methods for the synthesis of deuterated dextromethorphan
专利号:US-10865187-B2 优先权日:2016-07-04 标题 :Methods for the synthesis of deuterated dextromethorphan
1: Rizzo A, Borio G, Sieira J, Van Dooren S, Overeinder I, Bala G, Pappaert G, Maj R, Osório TG, Terasawa M, Galli A, Cecchini F, Miraglia V, Ströker E, La Meir M, Brugada P, Chierchia GB, de Asmundis C. Ajmaline Testing and the Brugada Syndrome. Am J Cardiol. 2020 Nov 15;135:91-98. doi: 10.1016/j.amjcard.2020.08.024. Epub 2020 Aug 27. 135(11):513-5. German. doi: 10.1055/s-0030-1249197. Epub 2010 Mar 10. 55:1-87. doi: 10.1016/s0099-9598(01)55002-6. 31(7):153-5. 19:1381-2. Polish. 10(10):e005775. doi: 10.1161/CIRCEP.117.005775.
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