CAS: 42826-42-6; Pivalohydrazide

该化合物是一种2,2-二甲基丙酰酸的专门氢氮衍生物,通常用于有机合成和制药用途,其硬性新二苯基结构具有消毒障碍,在凝聚反应中,特别是在形成氢氮和其他含氮的乙基循环过程中,加强了选择性.该化合物是生产活性药物成分(API)和农用化学剂的多种中间体,在受管制条件下提供了更好的稳定性和回活动性.其高纯度和定义明确的分子结构使它适合研究和工业规模进程,需要精确的功能组变.氢氮溶剂有助于高效衍生,有利于开发有定制特性的新型化合物.

结构式图片

相似化合物

3619-17-8 754-10-9 40016-17-9

欧盟法规

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上下游产品

CAS号598-98-1 特戊酸甲酯 | CAS号75-98-9 三甲基乙酸 | CAS号3938-95-2 特戊酸乙酯 | CAS号3282-30-2 特戊酰氯 | CAS号1489-89-0 1-diethoxyphosp... | CAS号4195-19-1 1-(三甲基乙酰基)咪唑 | CAS号38449-51-3 3-叔丁基-5-巯基-1,2,4-三唑 | CAS号630-19-3 三甲基乙醛 | CAS号75-97-8 频那酮 | CAS号73396-58-4 4-氨基-5-叔丁基-4H-1... | CAS号251540-53-1 2-叔丁基-1,3,4-恶二唑 | CAS号66557-70-8 (2,2-DIMETHYL-P...

合成工艺路线路线简述

  • 合成目标产物 2,2-Dimethylpropionic Acid Hydrazide 主要起始原料 1-(Trimethylacetyl)Imidazole
  • (文献来源)合成步骤主要原料 1-(Trimethylacetyl)Imidazole
📜三甲基乙酸乙酯置于一水合肼体系中,化学反应生成 2,2-二甲基丙酰肼
参考文献:Wieland; Hintermaier; Dennstedt,Justus Liebigs Annalen Der Chemie,1927,Vol. 452,P. 10
标题:Wieland; Hintermaier; Dennstedt,Justus Liebigs Annalen Der Chemie,1927,Vol. 452,P. 10

海关参考信息

专利信息


专利号:US-10815194-B2
优先权日:2016-11-14
标题 :Process for the preparation of mono-protected α,ω-diamino alkanes
发明人:MENGE WIRO MICHAEL PETRUS BERNARDUS
权利人:BYONDIS BV
摘要:The present invention relates to a process for the synthesis of mono-protected α,ω-diamino alkanes, the use of said process in a process for the synthesis of a linker drug comprising an α,ω-diamino alkane moiety and the use of the process of the present invention in a process for preparing an antibody-drug conjugate comprising an α,ω-diamino alkane moiety.

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-2010137244-A1
优先权日:2006-07-13
标题 :Preparation and utility of hmg-coa reductase inhibitors
发明人:GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described.

专利号:US-4560752-A
优先权日:1984-03-02
标题:Phosphinates or phosphonates useful for control of weeds
发明人:LEE SHY-FUH
权利人:ZOECON CORP
摘要:Novel 5-(substituted amino)phenoxyalkyl-, phenylthioalkyl-, phenylsulfinylalkyl-, and phenylsulfonylalkylphosphinates and phosphonates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.

专利号:US-6663866-B1
优先权日:1996-08-28
标题:Stable radioiodine conjugates and methods for their synthesis
发明人:GOVINDAN SERENGULAM V
权利人:IMMUNOMEDICS INC
摘要:Methods are described for conjugating radioiodinated peptides to non-metabolizable carbohydrates with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising a carbohydrate-appended peptide are also provided. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

专利号:RU-2189985-C2
优先权日:1999-04-30
标 题 :Method of synthesis of derivative of 8-cyclo-pentyl-6-ethyl-3- (substituted)-5,8-dihydro-4h-1,2,3a,7,8-pentaaza-ac-indacene (variants) and intermediate compounds

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Collier, S. J.; McLaws, M. D., Science of Synthesis, (2007) 33, 524.
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