CAS: 30044-61-2; (R)-2-((Tert-Butoxycarbonyl)Amino)-3-(Tert-Butyldisulfanyl)Propanoic Acid

相似化合物

73724-43-3 501326-55-2 1013096-03-1

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号30044-51-0 S-叔丁基巯基L-半胱氨酸

📜N,N'-双(叔丁氧羰基)-L-胱氨酸置于盐酸,N-氯代丁二酰亚胺,锌体系中,用 二氯甲烷,水,乙酸乙酯 作为反应溶剂,化学反应 2.0H,反应生成 Boc-S-叔-丁基巯基-L-半胱氨酸
参考文献:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264
标题:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264

专利信息

专利号:US-4033940-A
优先权日:1975-11-12
标 题:Cyclization of peptides
发明人：HUGHES JOHN L; SEYLER JAY K; LIU ROBERT C
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing an amino terminal cystine residue and a cysteine residue located in a position within the amino acid sequence, to give a desired peptide, and placing such intermediate peptide in a solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace a molecule of cysteine from the amino terminal cysteine residue. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.