乙烯基乙酸置于氢溴酸,Petroleum Ether体系中,化学反应生成4-溴丁酸 参考文献:Boorman; Linstead; Rydon,Journal Of The Chemical Society,1933,P. 573 标题:Boorman; Linstead; Rydon,Journal Of The Chemical Society,1933,P. 573
专利号:WO-03031376-A1 优先权日:2001-10-12 标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one 发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.
专利号:US-2023357132-A1 优先权日:2021-07-16 标题:SYNTHESIS OF mRNA DELIVERY AGENT 发明人:ZOU PING; ZUO ZHIWEI; QIU XIAOLONG; XU TAO; HU LIN; CHU LINGLING; LIU WENBO 权利人:WISDOM PHARMACEUTICAL CO LTD 摘要:The present disclosure relates to synthesis of an mRNA delivery agent, in particular to a reaction of a related amino compound with ethylene oxide in the presence of ytterbium triflate.
专利号:US-4400550-A 优先权日:1982-02-12 标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal 发明人:BISHOP CLYDE E; MORROW GARY W 权利人:ALBANY INT CORP 摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.
专利号:WO-2015183067-A1 优先权日:2014-05-30 标题 :Synthesis of analogues of y-amino acids and resulting products 发明人:FERNÃ?NDEZ ZERTUCHE MARIO; TOVAR GUDIÑO ERIKA; TRUJILLO FERRARA JOSÉ GUADALUPE; GUEVARA SALAZAR JUAN ALBERTO 权利人:UNIV AUTÓNOMA DEL ESTADO DE MORELOS 摘要:The invention relates to a compound of formula (see formula), suitable for use as drugs in the treatment of chronic neurodegenerative disorders of the Huntington's disease, Parkinson's disease and epilepsy type, inter alia . The invention relates to novel methods for the synthesis of said analogues and the pharmaceutically acceptable solvates and salts thereof.
专利号:US-2023148151-A1 优先权日:2020-04-17 标 题 :Process for the synthesis of a conjugate of hyaluronic acid and paclitaxel 发明人:CAMPISI MONICA; GUARISE CRISTIAN; PIZZOCARO CARLO 权利人:FIDIA FARM SPA 摘要:An industrial synthesis process of a hyaluronic acid-paclitaxel conjugate obtained by introducing the 4-bromobutyric acid spacer/linker between the hyaluronic acid and the paclitaxel, said conjugate being characterized by a high purity, the related pharmaceutical compositions for use in the treatment of multiple cancer forms are described.
专利号:US-12053529-B2 优先权日:2018-08-01 标题:Amino-reactive positively charged ATRP initiators that maintain their positive charge during synthesis of biomacro-initiators 发明人:RUSSELL ALAN J; MURATA HIRONOBU 权利人:UNIV CARNEGIE MELLON 摘要:Provided herein are materials and methods that include utilizing atom transfer radical polymerization (ATRP) initiator molecules that maintain a positive charge during biomacro-initiator synthesis.
参考标题:An Expedient Route For The Reduction Of Carboxylic Acids To Alcohols Employing 1-Propanephosphonic Acid Cyclic Anhydride As Acid Activator 作者:G. Nagendra,C. Madhu,T.M. Vishwanatha,Vommina V. Sureshbabu |发布日期:2012.9 摘要:Method For The Synthesis Of Alcohols From The Corresponding Carboxylic Acids Is Described. Activation Of Carboxylic Acid With 1-Propanephosphonic Acid Cyclic Anhydride (T3P) And Subsequent Reduction Using Nabh4 Yield The Alcohol In Excellent Yields With Good Purity. Reduction Of Several Alkyl/aryl Carboxylic Acids And Nα-Protected Amino Acids/peptide Acids As Well As Nβ-Protected Amino Acids Was Successfully
合成参考文献
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