CAS: 2319-57-5; (2S,3S)-Butane-1,2,3,4-Tetraol

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CAS号81028-07-1 4-benzyloxy-L-t... | CAS号95-44-3 L-(+)-苏糖 | CAS号35572-34-0 (-)-2,3-O-亚苄基-L-苏糖醇 | CAS号87-92-3 L-(+)-酒石酸二丁酯 | CAS号106-99-0 丁二烯 | CAS号141-46-8 羟乙醛 | CAS号60989-82-4 [(2S,3S)-3-(hyd... | CAS号50622-09-8 (+)-2,3-O-异亚丙基-L-苏糖醇 | CAS号608-68-4 L-(+)-酒石酸二甲酯 | CAS号87-91-2 L-(+)-酒石酸二乙酯 | CAS号533-50-6 L-赤藓酮糖 | CAS号4358-64-9 1,4-酐-赤藓糖醇 | CAS号84709-85-3 (3S,4s)-四氢呋喃-3,4-二醇 | CAS号87-69-4 酒石酸 | CAS号15410-44-3 2,3-Butanediol,...

📜L-(+)-苏糖置于rabbit 3-Hydroxyhexobarbital Dehydrogenase (Akr1C29),还原型辅酶ii(Nadph)四钠盐体系中,用 Aq. Phosphate Buffer,乙酸乙酯 用作溶剂,化学反应 0.5H,反应生成L-苏丁醇
参考文献:兔3-羟基己糖巴比妥脱氢酶是一种nadph优先的还原酶,对酮类固醇,前列腺素d(2)以及其他内源性和异源性羰基化合物具有广泛的底物特异性.
标题:兔3-羟基己糖巴比妥脱氢酶是一种nadph优先的还原酶,对酮类固醇,前列腺素d(2)以及其他内源性和异源性羰基化合物具有广泛的底物特异性.
摘要:3-羟基己异巴比妥脱氢酶(3Hbd)催化将nad(p)(+)链接的3-羟基己异巴比妥氧化为3-羟基己异巴比妥.该酶被认为是异生物醇和某些羟基类固醇的脱氢酶,但其生理功能仍然未知.我们已经纯化了兔3Hbd,分离了其cdna,并检查了其对辅酶和底物的特异性,反应方向性和组织分布.3Hbd是醛酮还原酶(akr)超家族的成员(akr1C29),并且在7.4的生理ph值下,Nadp(h)优于nad(h).在与nadph相关的还原反应中,3Hbd对多种醌,酮和醛(包括3-,17-和20-酮类固醇和前列腺素d(2))显示出广泛的底物特异性,它们被转化为3Alpha-,17Beta-和20Alpha-羟基类固醇和9Alpha,11Beta-前列腺素f(2),分别.特别是,α-二酮(如isatin和diacetyl)和脂质过氧化衍生的醛(如4-Oxo-和4-Hydroxy-2-Nonenals)是显示低k(m)值(0
Doi:10.1016/j.Bcp.2013.08.024

专利信息

专利号:US-5939304-A
优先权日:1997-06-05
标题:Method for synthesis of anhydrothrombin
发明人：SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI
权利人:FUJIMORI KOGYO CO
摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-5886190-A
优先权日:1993-10-04
标 题:Rapid synthesis and use of 18F-fluoromisonidazole and analogs
发明人：WALLACE SIDNEY; YANG DAVID J; CHERIF ABDALLAH
摘要:The present invention involves a rapid synthesis of 18F-FMISO and analogs thereof. New precursors such as 1-(2'-nitro-1'-imidazolyl)-2-0-acetyl-3-0-tosylpropanol, glycerol-1,3-ditosylate-2-0-acetylate, 1-(2'-nitro-1'-imidazolyl)-2,3-0-diacetyl-4-0-tosylbutanol and threitol 1,4-di-tosylate-2,3-0-diacetylate, are also important aspects of the invention. A further aspect of the invention is the development of a hydrophilic PET ligand to image tumor hypoxia. Erythrotosyl analogue of 2-nitroimidazone (Ts-ETNIM) was prepared from a mixture of 2-nitromidazole, ditosylthreitol and cesium carbonate at 60 DEG C. for 1 hr. Ts-ETNIM was isolated at 70% yield. [18F]fluoroerythronitroimidazole (FETNIM) was then prepared from Ts-ETNIM and K18F/kryptofix TM . The yield for [18F]FETNIM was 26-30% (60 min, decay corrected). Results of biodistribution and PET studies indicate that [18F]FETNIM has the potential to detect tumor hypoxia and is indicated to be less neurotoxic.

专利号:EP-0882789-A2
优先权日:1997-06-05
标 题:Method for synthesis of anhydrothrombin

专利号:WO-9509844-A1
优先权日:1993-10-04
标 题 :Rapid synthesis and use of 18f-fluoromisonidazole and analogs