CAS: 22029-76-1; 4-(2,6,6-Trimethylcyclohex-1-En-1-yl)But-3-En-2-Ol

相似化合物

14901-07-6 79-77-6 5208-93-5

上下游产品

(E)-β-ionone aluminum isopropoxide isopropyl alcohol Trimethyl-[(E)-1-methyl-3-(2,6,6-trimethyl-cyclohex-1-enyl)-allyloxy]-silane(E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-yl acetate O-isobutyryl-trans-β-ionol(+/-)-O-isobutyryl-trans-β-ionol β-ionyl phenyl sulfone (E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1-buten-3-yltriphenylphosphonium bromide

📜Beta-紫罗酮置于c29H34Bnop2Ru体系中,用 乙醇,二氯甲烷 用作溶剂,以91%的收率获得β-紫罗兰醇
参考文献:以iproh或etoh为氢源的α,β-不饱和羰基化合物的选择性无碱转移加氢
标题:以iproh或etoh为氢源的α,β-不饱和羰基化合物的选择性无碱转移加氢
摘要:商业上可买到的ru‐macho Tm ‐ Bh是一种活性催化剂,可用于多个官能团的加氢和醇的脱氢.在此,我们报道了该催化剂在羰基化合物的无碱转移加氢中的新应用.即使使用α,β-不饱和羰基化合物作为底物,Ru‐macho Tm ‐ Bh在此转化过程中也被证明具有很高的活性和选择性.在很短的反应时间后,在温和的温度下,催化剂的负载量低至0.1-0.5 Mol%,从而以优异的收率获得了相应的脂肪族,芳香族和烯丙基醇.这个协议可以容忍我proh和etoh为氢源.此外,在不损失活性或选择性的情况下,可进行放大至几克的量.提出了一种外球机理,巴豆醛和1-苯基-丁-2-烯酮的计算动力学和热力学与实验完全吻合.
Doi:10.1002/chem.201705423

专利信息

专利号:US-4125735-A
优先权日:1975-03-20
标 题 :Synthesis of esters of acetylenic alcohols
发明人：CLOSE RALPH E; OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A process for the synthesis of perfume products, Vitamin E and intermediates described herein involving a coupling reaction. For instance, a process for the synthesis of dehydrophytol and Vitamin E comprising forming a C15 acetylene from hexahydropseudoionone and then coupling said acetylene with 1-acetoxy-4-chloro-3-methylbut-2-ene to form a C20 acetoxy-enyne. The latter is readily subjected to partial hydrogenation and saponification in that order to form a dehydrophytol, a useful intermediate for the synthesis of Vitamin E and other products.

专利号:US-4039591-A
优先权日:1975-03-20
标 题:Synthesis of dehydrophytol and Vitamin E
发明人：CLOSE RALPH E; OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A process for the synthesis of dehydrophytol and Vitamin E comprising forming a C15 acetylene from hexahydropseudoionone and then coupling said acetylene with 1-acetoxy-4-chloro-3-methylbut-2-ene to form a C20 acetoxy-enyne. The latter is readily subjected to partial hydrogenation and saponification in that order to form a dehydrophytol, a useful intermediate for the synthesis of Vitamin E and other products.

专利号:US-4115466-A
优先权日:1975-10-16
标题:Synthesis of acetylenic compounds useful in preparing dehydrophytols and Vitamin E
发明人：CLOSE RALPH E; OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A process for the synthesis of an acetylenic hydrocarbon from an acetylenic carbinol which involves first replacing the hydroxyl group of the carbinol with a halogen to form a propargylic halide, dehalogenating the propargylic halide to form an allene, and isomerizing said allene to the desired acetylene. The present invention is particularly useful in the synthesis of Vitamin E.

专利号:US-4035425-A
优先权日:1973-04-23
标 题 :Synthesis of Vitamin A, intermediates and conversion thereof to Vitamin A
发明人：OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A synthesis of novel Vitamin A intermediates from beta-ionone is described as well as a conversion of the intermediates to Vitamin A. The length of the conjugated aliphatic side chain of beta-ionone is increased while still ultimately obtaining the desired trans form of Vitamin A. In general, beta-ionone is ethynylated to ethynyl-beta-ionol, the hydroxyl of which is etherified to form an ethynyl-terminated, alkoxy-substituted, beta-ionol intermediate. The intermediate is coupled through its copper derivative with a compound like chloro-isopentenyl acetate to produce a C20 skeleton. By semi-hydrogenation, the acetylenic bond on the C20 skeleton is converted to an ethylenic bond, and by hydrolysis the terminal ester moiety is converted to a hydroxyl group. Treatment with a strong base removes the alkoxy group to produce Vitamin A.

专利号:US-4092366-A
优先权日:1975-04-10
标题:Synthesis of Vitamin A, intermediates and conversion thereof to Vitamin A
发明人：OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A synthesis of novel Vitamin A intermediates from betaionone is described as well as a conversion of the intermediates to Vitamin A. The length of the conjugated aliphatic side chain of beta-ionone is increased while still ultimately obtaining the desired trans form of Vitamin A. In general, beta-ionone is ethynylated to ethynyl-beta-ionol, the hydroxyl of which is etherified to form an ethynyl-terminated, alkoxy-substituted, beta-ionol intermediate. The intermediate is coupled through its copper derivative with a compound like chloro-isopentenyl acetate to produce a C20 skeleton. By semi-hydrogenation, the acetylenic bond on the C20 skeleton is converted to an ethylenic bond, and by hydrolysis the terminal ester moiety is converted to a hydroxyl group. Treatment with a strong base removes the alkoxy group to produce Vitamin A.

专利号:US-3949006-A
优先权日:1972-04-24
标题:Synthesis of vitamin A, intermediates and conversion thereof to vitamin A
发明人：OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A synthesis of novel Vitamin A intermediates from betaionone is described as well as a conversion of the intermediates to Vitamin A. The length of the conjugated aliphatic side chain of beta-ionone is increased while still ultimately obtaining the desired trans form of Vitamin A. In general, beta-ionone is ethynylated to ethynyl-beta-ionol, the hydroxyl of which is etherified to form an ethynyl-terminated, alkoxy-substituted, beta-ionol intermediate. The intermediate is coupled through its copper derivative with a compound like chloro-isopentenyl acetate to produce a C20 skeleton. By semi-hydrogenation, the acetylenic bond on the C20 skeleton is converted to an ethylenic bond, and by hydrolysis the terminal ester moiety is converted to a hydroxyl group. Treatment with a strong base removes the alkoxy group to produce Vitamin A.