CAS: 204205-90-3; 2-[1-[(4-Chlorophenyl)Methyl]Indol-3-Yl]-2-Oxo-N-Pyridin-4-Ylacetamide

上下游产品

2-[1-(4-Chlorobenzyl)-1H-Indol-3-Yl]-2-Oxoacetyl Chloride 348111-64-8

📜1-[(4-氯苯基)甲基]吲哚 以 N,N-二甲基甲酰胺 用作溶剂,化学反应 6.5H,反应生成2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
参考文献:Synthesis And Characterization Of The Biologically Active 2-[1-(4-Chlorobenzyl)-1H-Indol-3-Yl]-2-Oxo-N-Pyridin-4-Yl Acetamide
标题:Synthesis And Characterization Of The Biologically Active 2-[1-(4-Chlorobenzyl)-1H-Indol-3-Yl]-2-Oxo-N-Pyridin-4-Yl Acetamide
摘要:
Doi:10.1002/1099-0690(200110)2001:20<3843::Aid-Ejoc3843>3.0.Co;2-P

专利信息

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.