CAS: 138-56-7; N-(4-(2-(Dimethylamino)Ethoxy)Benzyl)-3,4,5-Trimethoxybenzamide

上下游产品

benzylamine4-2-(dimethylamino)ethoxybenzylamine 3,4,5-Trimethoxybenzoyl chloride Eudesmic acid 4-(2-dimethylaminoethoxy)benzaldehydeN-[p-[(2-dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide hydr°Chloride

3,4,5-三甲氧基-N-苯基苯甲酰胺置于4-二甲氨基吡啶体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 30.0H,反应生成曲美苄胺
参考文献:N-C裂解制备仲酰胺的无金属氨基转移
标题:N-C裂解制备仲酰胺的无金属氨基转移
摘要:酰胺基转移反应代表了一个基本的化学过程,涉及一个酰胺官能团向另一个酰胺官能团的转化.在这里,我们报告一个浅显的,高度化学选择性方法的转-ñ-叔-丁氧基羰基化(n-Boc)活化的仲酰胺,在没有任何添加剂的情况下,在极其温和的条件下进行.由于该反应是在不存在金属,氧化剂或还原剂的情况下进行的,因此该反应具有许多有用的功能.该反应与各种酰胺和亲核胺相容,通过直接亲核加成至酰胺键,以优异的收率提供了转酰胺基化产物.直接从酰胺键合成市售止吐药tigan时,强调了该方法的实用性.我们预期,这种新的无金属的氨基转移将对涉及将直接亲核加成酰胺键作为关键步骤的新转化的发展产生广泛的影响.
Doi:10.1021/acs.Joc.9B02013

专利信息

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:WO-0054773-A1
优先权日:1999-03-12
标题:Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
发明人：GARVEY DAVID S
权利人:NITROMED INC; GARVEY DAVID S
摘要:The present invention is directed to novel compositions comprising at least one dopamine agonist in combination with at least one nitric oxide donor (i.e. compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are substrates for nitric oxide synthase). The novel compositions may optionally comprise at least one therapeutic agent, such as, a vasoactive agent, an antimetic agent, and mixtures thereof. The dopamine agonist is preferably apomorphine. The present invention is also directed to methods for treating and/or preventing sexual dysfunctions and/or enhancing sexual responses in patients. In other embodiments, the present invention is directed to methods treating or preventing neurodegenerative diseases, mitochondrial diseases, spinal cord injury, central or psychostimulant addiction, senile dementia, circulatory disorders, cardiovascular disorders, hyperprolactinaemia or myopia. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:US-2009298891-A1
优先权日:2005-09-16
标 题:Methods of Treating or Preventing Cancer Using Pyridine Carboxaldehyde Pyridine Thiosemicarbazone Radiosensitizing Agents
发明人：TOFILON PHILIP; CAMPHAUSEN KEVIN; GIUS DAVID
权利人:US GOV HEALTH & HUMAN SERV
摘要:The present invention features methods of inhibiting ribonucleotide reductase and DNA synthesis after administration of a dose of ionizing radiation to cells. The present invention further features methods of treating patients suffering from cancer comprising contemporaneous or sequential administration of a radiosensitizing dose of a 2-carboxyaldehyde pyridine thiosemicarbazone compound and ionizing radiation.

专利号:US-2008227851-A1
优先权日:2007-03-12
标题 :Laulimalide and laulimalide analogs
发明人：WENDER PAUL A
权利人:WENDER PAUL A
摘要:Novel laulimalide analogs, methods for the treatment of proliferative disease and processes for the synthesis of laulimalide and novel laulimalide analogs are described.

专利号:US-2005282898-A1
优先权日:2004-06-01
标 题 :Methods for the synthesis of milnacipran and congeners thereof