📜15-Hexadecenoic Acid置于氢溴酸,Potassium Carbonate,丁酮,Petroleum Ether,过氧化苯甲酰体系中,化学反应生成氧杂环十七烷-2-酮 参考文献:Plesek,Collection Of Czechoslovak Chemical Communications,1957,Vol. 22,P. 49,51 标题:Plesek,Collection Of Czechoslovak Chemical Communications,1957,Vol. 22,P. 49,51
专利号:US-5981240-A 优先权日:1996-11-27 标题:Enzyme-catalyzed synthesis of macromolecules in organic solvents 发明人:AKKARA JOSEPH A; BRUNO FERDINANDO F 权利人:US ARMY 摘要:A method is described for a simple, fast and efficient synthesis of homopolymers and copolymers by the enzymatic ring opening polymerization of lactones and lactides. The enzyme used is an ion paired protease. The advantage of this enzymatic system is in using small amount of enzyme per monomer and lower reaction time. Homopolymers and copolymers are synthesized with molecular weights between 1000 and 4600 daltons, and dispersity as low as 1.1. The monomer conversion after 4 days, for reactions catalyzed by protease S, has reached 100%. Different initiators are used to control the rate and degree of polymerization. Synthesis of block copolymers with defined block size and crystallinity are described in this invention. These biodegradable and bioerodable polyesters and copolyesters with controlled molecular weight, dispersity and crystallinity have applications in medical, drug, cosmetic and food industries.
专利号:US-7893286-B2 优先权日:2007-06-01 标题 :Method for the synthesis of phospholipid ethers 发明人:PINCHUK ANATOLY; WEICHERT JAMEY P; LONGINO MARC 权利人:CELLECTAR INC 摘要:Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.
专利号:US-5502226-A 优先权日:1994-11-14 标 题:Process of preparing ω-hydroxy acids 发明人:CHO SUK H; DEFLORIO VICTOR 权利人:ARDEN ELIZABETH CO 摘要:A new synthesis of omega -hydroxy acids, which employs commercially available starting materials and lowers the cost of production. The process involves coupling a fatty acyl group by enamine chemistry, followed by a ring expansion and selective reduction of ketoacid.
专利号:US-9567430-B2 优先权日:2011-12-02 标 题 :Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery 发明人:SALTZMAN W MARK; JIANG ZHAOZHONG; ZHOU JIANGBING; LIU JIE 权利人:UNIV YALE 摘要:Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.
专利号:WO-2013082529-A1 优先权日:2011-12-02 标题 :Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery 发明人:SALTZMAN W MARK; JIANG ZHAOZHONG; ZHOU JIANGBING 权利人:UNIV YALE 摘要:Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticies therefrom, and methods of using the nanoparticies for drug delivery are disclosed. The nanoparticies can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticies are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticies are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.
专利号:US-8022235-B2 优先权日:2007-06-01 标 题 :Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use 发明人:PINCHUK ANATOLY; WEICHERT JAMEY P; LONGINO MARC 权利人:CELLECTAR INC 摘要:The present invention discloses boronic acids and esters of phospholipid ether analogs and methods for their synthesis and use. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells.
参考文献:10.1007/b14130 摘要:Food and Cosmetics Toxicology., 13(452), 1975 摘要:Maier, M. E., Science of Synthesis, (2007) 20, 1465. 摘要:Maier, M. E., Science of Synthesis, (2007) 20, 1456.