CAS: 106447-44-3; 7-Amino-8-Oxo-3-[(1Z)-1-Propen-1-Yl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid

上下游产品

(7R,8R)-7-phenylacetamido-3-[propen-1-yl]-3-cephem-4-carboxylic acid p-methoxybenzyl ester N,O-bis-(trimethylsilyl)-acetamide acetaldehyde 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid cefprozil

📜Diphenylmethyl 7β-Amino-3-<(Z)-1-Propenyl>-3-Cephem-4-Carboxylate 反应生成7-氨基-8-氧代-3-[(1Z)-1-丙烯-1-基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
参考文献:Hoshi,Hideaki;Okumura,Jun;Naito,Takayuki;Abe,Yoshio;Aburaki,Shimpei
标题:Hoshi,Hideaki;Okumura,Jun;Naito,Takayuki;Abe,Yoshio;Aburaki,Shimpei

专利信息

专利号:US-5132419-A
优先权日:1989-10-03
标题 :Process for the preparation of 7-amino-3-((z)-1-propen-1yl)-3-cephem-4-carboxylic acid
发明人：LANZ JOACHIM; NAAB PAUL; ROSENTRETER ULRICH
权利人:BAYER AG
摘要:(7-APCA) having the formula (I) ##STR1## which is an important synthesis intermediate in the preparation of cephalosporin-like antibiotics, is prepared by treating a compound of the formula (II) ##STR2## in which R 1 and R 2 represent alkyl, aryl and aralkyl radicals, with a strong protonic acid or with a Lewis acid. Compound (II) is prepared by adding triphenylphosphine and alkali metal iodide to a compound of the formula (VI) ##STR3## then reacting with acetaldehyde in base. Compound (VI) is prepared by treating a compound of the formula (VII) ##STR4## with a base in a polar solvent at -70° C. to 0° C. Compound (VII) is prepared by treating a compound of the formula (VIII) ##STR5## with a chlorinating agent in an organic solvent.

专利号:WO-2010082108-A1
优先权日:2009-01-16
标题:Improved process for preparation of key intermediate of cephalosporins
发明人：SAHOO PRABHAT KUMAR; SHRIVASTAVA AJAY KUMAR; YADAV CHHANNU LAL; CHAUBEY BIPIN KUMAR
权利人:NECTAR LIFESCIENCES LTD; SAHOO PRABHAT KUMAR; SHRIVASTAVA AJAY KUMAR; YADAV CHHANNU LAL; CHAUBEY BIPIN KUMAR
摘要:An improved process for the preparation of 7-phenylacetamido-3-vinyl cephalosporanic acid-p-methoxybenzyl ester of formula (I), which is a key intermediate of cephalosporin antibiotics and is extremely useful in their synthesis, is provided. More particularly, an improved process for the preparation of a compound of formula (I) by using a compound of formula (A) is provided, wherein, R represents hydrogen, alkyl, aryl or arylalkyl, which may be same or different and may be further substituted, making it a substantially cost effective and eco-friendly procedure.

专利号:CN-102875576-A
优先权日:2012-10-31
标 题:Synthesis of an antibiotic ceftazidime, ceftazidime for injection and preparation method thereof

专利号:LU-503177-B1
优先权日:2022-12-12
标题:Preparation method for enzymatic synthesis of cefprozil

专利号:CN-103451259-A
优先权日:2013-08-07
标 题:Catalytic synthesis of cefprozil by immobilized penicillin acylase in a reusable two-phase aqueous system

专利号:CN-108017658-B
优先权日:2017-12-26
标题:Synthesis method of cefprozil