CAS: 10191-41-0; 2,5,7,8-Tetramethyl-2-(4,8,12-Trimethyltridecyl)Chroman-6-Ol

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CAS号505-32-8 异植物醇 | CAS号700-13-0 三甲基氢醌 | CAS号7559-04-8 α-托可醌 | CAS号36148-84-2 亚油酸-3,4-二氢-2,5,... | CAS号77171-97-2 α-t°Copherol | CAS号59-02-9 维生素E油 | CAS号766-07-4 cyclohexyl hydr... | CAS号56306-89-9 2,2,5,7,8-penta...

6-Methoxy-2,5,7,8-Tetramethyl-2-(4,8,12-Trimethyltridecyl)Chromane置于aluminum (III) Chloride,三氟二甲基硫醚络合物体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 6.0H,以86%的收率获得dl-α-生育酚
参考文献:通过苯并环化/邻醌甲基化物形成/电环化级联同时合成色烯的两个环
标题:通过苯并环化/邻醌甲基化物形成/电环化级联同时合成色烯的两个环
摘要:开发了一种色烯环体系的新路线,该路线涉及铬的α,β-不饱和费歇尔卡宾络合物与在炔丙碳上带有烯基的炔丙醚的反应.这种转化涉及一系列反应,从苯并环化反应开始,然后形成邻醌甲基化物,最后在电环化时产生色烯.通过使用芳基卡宾络合物,该反应被扩展以提供通路.这是色烯的首次合成,其中色烯系统的两个环均在一步中生成,并在 Lapachenole 和维生素 E 的合成中得到突出体现.
Doi:10.1021/ja210655G

专利信息

专利号:US-4125735-A
优先权日:1975-03-20
标 题 :Synthesis of esters of acetylenic alcohols
发明人：CLOSE RALPH E; OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A process for the synthesis of perfume products, Vitamin E and intermediates described herein involving a coupling reaction. For instance, a process for the synthesis of dehydrophytol and Vitamin E comprising forming a C15 acetylene from hexahydropseudoionone and then coupling said acetylene with 1-acetoxy-4-chloro-3-methylbut-2-ene to form a C20 acetoxy-enyne. The latter is readily subjected to partial hydrogenation and saponification in that order to form a dehydrophytol, a useful intermediate for the synthesis of Vitamin E and other products.

专利号:US-4185154-A
优先权日:1977-05-17
标 题 :Synthesis of vitamin E
发明人：OLSON GARY L; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.

专利号:US-10695450-B2
优先权日:2016-07-26
标 题 :Synthesis of a radioactive agent composition
发明人：VIOT GILLES
权利人:LABORATOIRES CYCLOPHARMA
摘要:The present invention relates to a method for the synthesis of a radioactive agent composition comprising at least a purification step carried out in the presence of an antioxidant, to the composition obtained by this method comprising radioactive agent and excipient, and to the method for preventing radiolysis of radioactive agent composition comprising the synthesis of said radioactive agent according to the method of the invention.

专利号:US-4182719-A
优先权日:1977-05-17
标题 :Synthesis of optically active vitamin E
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.

专利号:US-4277610-A
优先权日:1975-01-27
标 题 :Synthesis of 2,6,10-trimethyl-undecan-1-ol
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, β-hydroxy-isobutyric acid including intermediates in this synthesis.

专利号:US-4243598-A
优先权日:1977-05-17
标题:Synthesis of vitamin E
发明人：OLSON GARY L; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:1 A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.