CAS: 948-54-9; 1-(Bromo(Phenyl)Methyl)-4-Chlorobenzene

该化合物是一种有机化合物,其特征是苯环上同时存在溴和氯替代物,该化合物的特性是联苯甲基组的溴组,该化合物与氯苯系有进一步的联系.分子结构表明,这是一种卤代芳香化合物,由于存在这些卤素原子,这种化合物往往具有独特的反应性.这种化合物通常会参与电子生物替代反应,并可能由于溴组的存在而发生核生殖器替代.这种化合物的物理特性,如沸点,熔点和溶性,可能因其分子相互作用和存在代产物而不同.此外,此类卤代物因其潜在的生物活动和合成中的实用性,在各个领域,包括制药和材料科学,都具有特别的兴趣.在处理这种化合物时,应当采取安全防范措施,因为卤化有机化合物可能构成健康和环境风险.

英文名称1-(Bromo(Phenyl)Methyl)-4-Chlorobenzene
中文名称1-(溴苯甲基)-4-氯苯
IUPAC名称1-(bromo(phenyl)methyl)-4-chlorobenzene
其它别名1-(Bromophenylmethyl)-4-Chlorobenzene; Cetirizine Impurity N; 4-Chlorodiphenylmethyl Bromide; Benzene, 1-(Bromophenylmethyl)-4-Chloro-
CAS编号948-54-9
MFCD编号:MFCD09833429
分子式:C13H10BrCl分子量:281.58
产品CID: 2001104
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: MPUGMNSVMMFEOE-UHFFFAOYSA-N
InChI=1S/C13H10BrCl/c14-13(10-4-2-1-3-5-10)11-6-8-12(15)9-7-11/h1-9,13H
计算化学: 氢键受体数*氢键供体数*可旋转键数2.0

MSDS等安全信息

上下游产品

CAS号119-56-2 4-氯二苯甲醇 | CAS号134-85-0 4-氯二苯甲酮 | CAS号831-81-2 4-氯二苯基甲烷 | CAS号119-56-2 4-氯二苯甲醇

合成工艺路线路线简述

119-56-2 = 948-54-9
反应条件:1.1 Reagents: Phosphorus Tribromide Solvents: Chloroform,Diisopropyl Ether; Cooled; 1 H,Rt
标题:Preparation Of Tricyclic Compounds As Prostaglandin I2 Receptor Agonists
参考文献:World Intellectual Property Organization]

831-81-2 = 948-54-9
反应条件:1.1 Reagents: Bromine Catalysts: Benzoyl Peroxide; Rt -> 131 °C; 0.5 H,131 °C; 2 H,131 °C
标题:Improvement For Synthesis Process Of Cetirizine Hydrochloride
作者:Liu,Bue
参考文献:Guangdong Huagong 日期:2008 卷标:35(9) 页码:66-67]

831-81-2 = 948-54-9
反应条件:1.1 Reagents: Bromine Solvents: Carbon Tetrachloride; 1.5 H,Reflux
标题:Improved Synthesis Of Cetirizine Hydrochloride
作者:Wang,Jian-Jun; Yang,Xue-Yan; Wu,Fan-Hong
参考文献:Huadong Ligong Daxue Xuebao 日期:2002 卷标:28(6) 页码:668-670]

831-81-2 = 948-54-9
反应条件:1.1 Reagents: Bromine; 118 °C; 8 H,118 °C
标题:Method For Preparation Of Chlorcyclizine Hydrochloride
参考文献:China]

831-81-2 = 948-54-9
反应条件:1.1 Reagents: Bromine; 1.5 - 2 H,Rt; Rt -> 55 °C; 5 - 6 H,50 - 55 °C; 55 °C -> Rt1.2 Reagents: Sodium Carbonate,Sodium Sulfate; 1 H,Rt
标题:Method For Synthesizing Chlorcyclizine Hydrochloride
参考文献:China]

= 948-54-9 [标题:Reaction Conditions
标题:Synthesis And Anticonvulsant Activity Of Some Cinnamylpiperazine Derivatives
作者:Hu,Chuan; Sun,Zhi-Gang; Wei,Cheng-Xi; Quan,Zhe-Shan
参考文献:Letters In Drug Design & Discovery 日期:2010 卷标:7(9) 页码:661-664]

= 948-54-9 [标题:Reaction Conditions
标题:Reactions Of Halometal Alcoholates. Lxxvi. Anomalous Courses Of The Reactions Of Aromatic Ketones With Organomagnesium Compounds
作者:Lapkin,I. I.; Khokhryakova,N. P.; Rybakova,M. N.
参考文献:Sintetich. Metody Na Osnove Metalloorgan. Soedinenii. 日期:1977 卷标:71 页码:71-6]

119-56-2 = 948-54-9
反应条件:1.1 Reagents: Phosphorus Pentoxide,Potassium Bromide Solvents: Acetonitrile; 60 Min,Rt
标题:An Efficient And Selective Method For The Iodination And Bromination Of Alcohols Under Mild Conditions
作者:Khazdooz,Leila; Zarei,Amin; Aghaei,Hamidreza; Azizi,Ghobad; Gheisari,Mohammad Mehdi
参考文献:Tetrahedron Letters 日期:2016 卷标:57(2) 页码:168-171]

119-56-2 = 948-54-9
反应条件:1.1 Reagents: Hydrogen Bromide Catalysts: Tetrabutylammonium Bromide Solvents: Water; Rt1.2 Reagents: Sulfuric Acid Solvents: Water; Cooled; 2 H,Reflux; Cooled1.3 Reagents: Water; Cooled
标题:Preparation Of 1-[bromo(Phenyl)Methyl]-4-Chlorobenzene Via By Phase Transfer Catalysis
作者:Kang,Huaiping; Wang,Juan; Liu,Yuzhen; Nie,Xinyong
参考文献:Huaxue Shijie 日期:2006 卷标:47(1) 页码:36-37]

119-56-2 = 948-54-9
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Toluene,Water; 15 Min,75 °C1.2 Reagents: Sulfuric Acid; 3 H,75 - 80 °C; 1 H,75 - 80 °C; 80 °C -> Rt1.3 Reagents: Sodium Carbonate Solvents: Toluene,Water; Neutralized
标题:Synthesis Of 1-[(4-Chlorophenyl) Phenyl Methyl] Piperazine
作者:Dong,Chuan-Ming; Chu,Ji-Cheng; Li,Mao-Xia
参考文献:Meitan Yu Huagong 日期:2014 卷标:37(1) 页码:83-84]

119-56-2 = 948-54-9
反应条件:1.1 Reagents: Thionyl Bromide Solvents: Dichloromethane; Cooled; 4 H,Rt
标题:Pyrimidinone Derivatives And Their Preparation,And Use In The Treatment Of Gpr119-Related Diseases
参考文献:World Intellectual Property Organization]

119-56-2 = 948-54-9 [标题:Reaction Conditions
标题:Substituted Piperazines
参考文献:German Democratic Republic]

= 948-54-9 [标题:Reaction Conditions
标题:Preparation Of Atarax (Hydroxyzine Hydrochloride)
作者:Yu,I-Ch'Eng; Lui,Ch'Uan-Ming; Lu,Chung-Lin
参考文献:Yaoxue Xuebao 日期:1966 卷标:13(7) 页码:514-17]

119-56-2 = 948-54-9 + 134-85-0
反应条件:1.1 Reagents: Oxygen,Aluminum Bromide (Albr3),Hexahydrate Solvents: 1,4-Dioxane; 4 H,70 °C
标题:Albr3.6H2O Catalyzed Oxidation Of Benzylic Alcohols
作者:Zhong,Yun-Mei; Ma,Heng-Chang; Wang,Jin-Xia; Jia,Xiao-Jie; Li,Wen-Feng; Et Al
参考文献:Catalysis Science & Technology 日期:2011 卷标:1(6) 页码:927-931

📜4-氯二苯甲酮置于sodium Tetrahydroborate,氢溴酸体系中,化学反应生成 1-(溴苯甲基)-4-氯苯
参考文献:肉桂基哌嗪衍生物的合成及其抗惊厥活性
标题:肉桂基哌嗪衍生物的合成及其抗惊厥活性
摘要:以不同的二苯甲酮为原料合成了一系列肉桂基哌嗪衍生物.化合物的结构由其ir,1 H-NMR光谱数据和质谱数据证实.这些化合物的抗惊厥活性通过最大电击(mes)试验和腹膜内注射的rotarod试验在昆明小鼠上进行评估.在所有氟尿利嗪类似物中,没有人比氟尿利嗪具有更好的抗惊厥活性.氟硝利嗪(4I)表现出抗惊厥活性,通过腹膜内给药,Ed50为38.1 Mg / Kg,Td50为164.3 Mg / Kg,Pi为4.3,口服ed50为56.8 Mg / Kg,Td50为456.3 Mg / Kg,Pi为8.0行政.
DOI:10.2174/157018010792929595