CAS: 931204-39-6; (S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)-2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid

英文名称(S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)-2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid
中文名称利伐沙班杂质 18
IUPAC名称(S)-2-(2-((4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)amino)ethoxy)acetic acid
其它别名Rivaroxaban Impurity 15; Rivaroxaban Impurity G: Rivaroxaban Ring Opener; Rivaroxaban Acetoxalamide Impurity; Rivaroxaban M; Rivaroxaban Open-Ring Acid Impurity; Rivaroxaban Impurity 11/(S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)-2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid; Rivaroxaban Impurity A; 2-({4-[(5S)-5-({[(5-Chloro-2-Thienyl)Carbonyl]Amino}Methyl)-2-Oxo-1,3-Oxazolidin-3-Yl]Phenyl}-Amino)Ethoxyacetic Acid
CAS编号931204-39-6
MFCD编号:MFCD28358882
FDA UNII编号:UZ8PC8MPJ4
分子式:C19H20ClN3O6S
分子量:453.9
产品CID: 1969890
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: AONZTKUREAFWOY-AWEZNQCLSA-N
InChI=1S/C19H20ClN3O6S/c20-16-6-5-15(30-16)18(26)22-9-14-10-23(19(27)29-14)13-3-1-12(2-4-13)21-7-8-28-11-17(24)25/h1-6,14,21H,7-11H2,(H,22,2…
计算化学: 氢键受体数8.0氢键供体数3.0可旋转键数10.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P501-
安全声明CAUT

上下游产品

2-({4-[(5S)-5-({[(5-chloro-2-thienyl)carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-amino)ethoxyacetic acid hydr°Chloride Rivaroxaban 2-{2-[1-(5-chlorothiophen-2-yl)-N-{4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}formamido]ethoxy}acetic acid

合成工艺路线路线简述

366789-02-8 = 931204-39-6
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetic Acid,Water; 6 H,Rt -> Reflux
标题:Method For Preparation Of Amide Compounds
参考文献:China]

366789-02-8 = 931204-39-6
反应条件:1.1 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Water; 4 H,Rt -> 80 °C
标题:Triamine Compound Related To Rivaroxaban,And Synthetic Method
参考文献:China]

366789-02-8 = 931204-39-6
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetic Acid,Water; Rt -> 60 °C; 5 H,60 °C
标题:One Kind Of Rivaroxaban Related Substance Of Diamine And Its Synthesis Method
参考文献:China]

366789-02-8 = 931204-39-6
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetic Acid,Water; 5 H,Rt -> 60 °C
标题:Preparation Of Rivaroxaban Related Diamine Substance
参考文献:China

利伐沙班置于盐酸,溶剂黄146体系中,用水作为反应溶剂,化学反应 5.0H,以92.2%的收率获得产物利伐沙班杂质18
参考文献:一种利伐沙班相关物质二胺的合成方法
标题:一种利伐沙班相关物质二胺的合成方法
摘要:一种利伐沙班相关物质二胺,能作为研究,并控制利伐沙班的对照品,且制备方法简便,原料易得.其结构式为:分子式:C25H24Cl2N4O4S2,分子量为610.5.本发明的利伐沙班相关物质二胺,能作为监控利伐沙班杂质的对照品.本发明的利伐沙班相关物质二胺的合成方法,操作简单,具有很好的实用性,能够产生较好经济效益和社会效益.