CAS: 865318-97-4; Ametoctradin

📜癸腈置于氯磺酸,Potassium Methanolate体系中,用 邻二甲苯 作为反应溶剂,化学反应 2.92H,反应生成 唑嘧菌胺
参考文献:Ametoctradin是一种有效的q ø线粒体呼吸复合物iii的位点抑制剂
标题:Ametoctradin是一种有效的q ø线粒体呼吸复合物iii的位点抑制剂
摘要:Ametoctradin是basf正在研发的一种新型卵菌特异性杀菌剂.它是线粒体呼吸作用中bc 1复合物的有效抑制剂.但是,其详细的作用机理仍然未知.在目前的工作中,首先通过整合分子对接,Md模拟和mm / Pbsa计算发现了met虫oct的结合模式,这表明a虫radi应该是bc 1复合物的q O部位抑制剂.随后,设计并合成了一系列新的1,2,4-三唑并[1,5-A]嘧啶衍生物,以进一步了解取代基对1,2,4-三唑并[1] 5和6位的影响.,5-一]嘧啶.计算出的新合成类似物作为q O部位抑制剂的结合自由能(δg Cal)与它们的实验结合自由能(δg Exp)很好地相关(r 2 = 0.96).已成功鉴定出两种化合物(4A和4C)对猪sqr的抑制活性高于阿美他汀.从本研究中获得的结构和力学见解将为将来设计新的有前途的bc 1抑制剂提供有价值的线索.
DOI:10.1021/acs.Jafc.5B00228

专利信息

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2011230343-A1
优先权日:2008-10-24
标题 :Method for the Manufacture of Microparticles Comprising an Effect Substance
发明人：SCHROERS MICHAEL; DYLLICK-BRENZINGER RAINER; MERK MICHAEL; BARG HEIKO
权利人:BASF SE
摘要:A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M. In addition, the present invention relates to the use of microparticles M prepared according to the invention as component in colorants, cosmetics, drugs, biocides, plant protection agents, fertilizers, additives for food or animal fodder, or auxiliaries for polymers, paper, textiles, leather, detergents or cleaners. Finally, the invention also relates to a method for combating undesirable plant growth, to a method for combating undesirable insect or acarid infestation on plants and/or for combating phytopathogenic fungi, and to seeds treated with the agrochemical formulation.

专利号:US-2015272130-A1
优先权日:2012-12-03
标 题:Composition comprising a biological control agent and a fungicide
发明人：WACHENDORFF-NEUMANN ULRIKE; DAHMEN PETER; SAWADA HARUKO
权利人:BAYER CROPSCIENCE AG
摘要:The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Paecilomyces lilacinus strain 251 (AGAL No. 89/030550) and Coniothyrium minitans CON/M/91-08 (DSM 9660) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against nematodes, insects and/or phytopathogens, and at least one fungicide (I) selected from the group consisting of compounds capable to introduce a host defence, inhibitors of the amino acid and/or protein biosynthesis, inhibitors of the ATP production, inhibitors of the cell wall synthesis, inhibitors of the lipid and membrane synthesis, inhibitors of the melanine biosynthesis, inhibitors of the nucleic acid synthesis, inhibitors of the signal transduction, compounds capable to act as an uncoupler, and other fungicides in a synergistically effective amount. Furthermore, the present invention relates to a kit of parts comprising said composition and the use of said composition.

专利号:US-2015105251-A1
优先权日:2012-05-30
标 题 :Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction

专利号:WO-2013178655-A1
优先权日:2012-05-30
标 题 :Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction

专利号:US-12102085-B2
优先权日:2013-10-18
标题 :Insecticidal active mixtures comprising carboxamide compound
发明人：SIKULJAK TATJANA; GEWEHR MARKUS
权利人:BASF AGROCHEMICAL PRODUCTS BV
摘要:The present invention relates to pesticidal mixtures comprising as active compound I an insecticidal active carboxamide derivative and at least one active compound II selected from a group M comprising acteylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acteylcholine receptor agonists/antagonists, allosteric nicotinic acetylcholine receptor activators, chloride channel activators, juvenile hormone mimics, homopteran feeding blockers, mit grow inhibitors, inhibitors of mitochondrial ATP synthase, uncouplers of the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, ecdyson receptor agonists, octamin receptor agonists, inhibitors of the MET, voltage-dependent sodium channel blockers, inhibitors of the lipid synthesis, ryanodine receptor modulators and other compounds as defined in the description, in synergistically effective amounts.The invention relates further to methods and use of these mixtures for combating and controlling insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting plant proparagation material, such as seeds.