CAS: 85-87-0; 4-(Aminomethyl)-5-(Hydroxymethyl)-2-Methylpyridin-3-Ol

• 英文名称4-(Aminomethyl)-5-(Hydroxymethyl)-2-Methylpyridin-3-Ol
• 中文名称吡多胺
• IUPAC名称4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol
• 其它别名Pyridoxamine ; 4-(Aminomethyl)-5-(Hydroxymethyl)-2-Methylpyridin-3-Ol ; 3-Pyridinemethanol, 4-(Aminomethyl)-5-Hydroxy-6-Methyl- ; 4-(Aminomethyl)-5-(Hydroxymethyl)-2-Methyl-3-Pyridinol
• CAS编号85-87-0
• MFCD编号:MFCD00464815
• EINECS号:201-640-5
• FDA UNII编号:6466NM3W93
• 分子式:C8H12N2O2
• 分子量:168.2
• 产品CID: 1857974
• 产品分类原料药 → 维生素类与矿物质类药 → 维生素B类药

• 相似结构搜索
• InChIKey: NHZMQXZHNVQTQA-UHFFFAOYSA-N
• InChI=1S/C8H12N2O2/c1-5-8(12)7(2-9)6(4-11)3-10-5/h3,11-12H,2,4,9H2,1H3…
• 计算化学: 氢键受体数4.0氢键供体数3.0可旋转键数2.0

物理性质

• 熔点193-193.5 °C
• 沸点460.1 °C at 760 mmHg
• 闪点232.1 °C
• 密度1.282g/cm3
• pKa:9.98±0.10(预测)
• PSA:79.37
• LogP:0.7469
• 折射率1.617
• 蒸汽压2.92E-09 mmHg at 25 °C
• 溶解性DMSO (Slightly), Methanol (Slightly)
• 外观形态淡黄色固体
• 储存条件防潮, 冰箱, 置于惰性气氛下
• 产品应用该化合物是先进的甘酸终端产品(AGES)和先进的脂脱氧最终产品(ALES)的抑制剂,防止糖尿病复丁酸病;它作为反应性碳基的强冲源,抑制导致形成乙基乙基苯的晚阶段甘化反应;它限制了N-(CARBOXYMOTHY)LYSINE(CML)和N(CBOXEY乙基)碱(CEL)的形成,以及皮肤凝胶中的交叉联系,从而抑制了血清对血清链菌素(STZ)诱发的糖尿病老鼠的发作;它防止脂过氧化产品对蛋白的改变,包括形成恶性肾上腺炎和4-羟丁酸酸性粘液在活性蛋白质上.

MSDS等安全信息

• 警示词Warning
• 危险描述H302-H315-H319-
• 防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-

上下游产品

合成工艺路线路线简述

• 708-08-7 = 85-87-0
  反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Platinum Dioxide Solvents: Ethanol
  标题:Platinum(Iv) Oxide
  作者:King,Anthony O.; Et Al
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-3]
  
  708-08-7 = 85-87-0 [标题:Reaction Conditions
  标题:Synthetic Studies Of Pyridoxine Derivatives. I. Synthesis Of 5-Substituted-3-(2-Methyl-3-Hydroxy-5-Hydroxymethyl-4-Pyridyl)Methyl-4-Methylthiazoline-2-Thiones
  作者:Ito,Isoo; Et Al
  参考文献:Yakugaku Zasshi 日期:1975 卷标:95(8) 页码:944-8]
  
  20905-67-3 = 85-87-0
  反应条件:1.1 Reagents: Zinc Solvents: Acetic Acid
  标题:A New Pyridoxamine Synthesis
  作者:Testa,Emilio; Et Al
  参考文献:Chimia 日期:1957 卷标:11]
  
  274250-28-1 + 85-87-0 = 85-87-0
  反应条件:1.1 Solvents: Water; 60 Min,Ph 9.4,60 °C1.2 Reagents: Methylamine; 30 Min,60 °C
  标题:Differential 12C-/13C-Isotope Dansylation Labeling And Fast Liquid Chromatography/mass Spectrometry For Absolute And Relative Quantification Of The Metabolome
  作者:Guo,Kevin; Et Al
  参考文献:Analytical Chemistry (Washington 日期:2009 卷标:81(10) 页码:3919-3932]
  
  66-72-8 = 85-87-0
  反应条件:1.1 Reagents: L-Alanine
  标题:Deuterium Isotope Effects In Transamination: L-Alanine And Pyridoxal
  作者:Blake,M. I.; Et Al
  参考文献:Journal Of The American Chemical Society 日期:1963 卷标:85 页码:294-7]
  
  = 85-87-0
  反应条件:1.1 Reagents: Phosphorus Pentachloride; 2 H,60 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized2.1 Solvents: Water; 60 Min,Ph 9.4,60 °C2.2 Reagents: Methylamine; 30 Min,60 °C
  标题:Differential 12C-/13C-Isotope Dansylation Labeling And Fast Liquid Chromatography/mass Spectrometry For Absolute And Relative Quantification Of The Metabolome
  作者:Guo,Kevin; Et Al
  参考文献:Analytical Chemistry (Washington 日期:2009 卷标:81(10) 页码:3919-3932]
  
  58-56-0 = 85-87-0
  反应条件:1.1 Reagents: Manganese Oxide (Mno2),Hydroxylamine2.1 -
  标题:Synthetic Studies Of Pyridoxine Derivatives. I. Synthesis Of 5-Substituted-3-(2-Methyl-3-Hydroxy-5-Hydroxymethyl-4-Pyridyl)Methyl-4-Methylthiazoline-2-Thiones
  作者:Ito,Isoo; Et Al
  参考文献:Yakugaku Zasshi 日期:1975 卷标:95(8) 页码:944-8]
  
  84-89-9 + 286013-18-1 = 85-87-0
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Water; Rt; 30 Min,Cooled; 30 Min,80 °C; 80 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 42.1 Reagents: Phosphorus Pentachloride; 2 H,60 °C2.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized3.1 Solvents: Water; 60 Min,Ph 9.4,60 °C3.2 Reagents: Methylamine; 30 Min,60 °C
  标题:Differential 12C-/13C-Isotope Dansylation Labeling And Fast Liquid Chromatography/mass Spectrometry For Absolute And Relative Quantification Of The Metabolome
  作者:Guo,Kevin; Et Al
  参考文献:Analytical Chemistry (Washington 日期:2009 卷标:81(10) 页码:3919-3932]
  
  20905-67-3 = 85-87-0
  反应条件:1.1 Reagents: Hydrogen,Dipyridinium Dichromate
  标题:Lipids. Ix. Synthesis Of Some Triglycerides Of Soybean Oil
  作者:Mitrofanova,T. K.; Et Al
  参考文献:Zhurnal Obshchei Khimii 日期:1961 卷标:31 页码:2984-6]
  
  15871-95-1 = 85-87-0 [标题:Reaction Conditions
  标题:Synthetic Studies Of Pyridoxine Derivatives. I. Synthesis Of 5-Substituted-3-(2-Methyl-3-Hydroxy-5-Hydroxymethyl-4-Pyridyl)Methyl-4-Methylthiazoline-2-Thiones
  作者:Ito,Isoo; Et Al
  参考文献:Yakugaku Zasshi 日期:1975 卷标:95(8) 页码:944-8]
  
  183552-44-5 = 85-87-0
  反应条件:1.1 Reagents: Ethylenediaminetetraacetic Acid,Aminotransferase
  标题:Enzymes By Design: Chemogenetic Assembly Of Transamination Active Sites Containing Lysine Residues For Covalent Catalysis
  作者:Haering,Dietmar; Et Al
  参考文献:Bioconjugate Chemistry 日期:2001 卷标:12(3) 页码:385-390]
  
  57755-34-7 = 85-87-0 [标题:Reaction Conditions
  标题:Synthetic Studies Of Pyridoxine Derivatives. I. Synthesis Of 5-Substituted-3-(2-Methyl-3-Hydroxy-5-Hydroxymethyl-4-Pyridyl)Methyl-4-Methylthiazoline-2-Thiones
  作者:Ito,Isoo; Et Al
  参考文献:Yakugaku Zasshi 日期:1975 卷标:95(8) 页码:944-8]
  
  65-23-6 = 85-87-0
  反应条件:1.1 Reagents: Sodium Acetate,Hydroxyamine Hydrochloride
  标题:Cancer-Specific Cytotoxicity Of Ringer'S Acetate Solution Irradiated By Cold Atmospheric Pressure Plasma
  作者:Miron,Camelia; Et Al
  参考文献:Free Radical Research 日期:2023 卷标:57(2) 页码:91-104]
  
  66-72-8 = 85-87-0 [标题:Reaction Conditions
  标题:Aminodiphosphonic Acids And Diaminodiphosphonic Acids - Synthesis And Transamination Behavior
  作者:Issleib,K.; Et Al
  参考文献:Phosphorus And Sulfur And The Related Elements 日期:1983 卷标:14(2) 页码:171-8]
  
  708-07-6 = 85-87-0 [标题:Reaction Conditions
  标题:Synthetic Studies Of Pyridoxine Derivatives. I. Synthesis Of 5-Substituted-3-(2-Methyl-3-Hydroxy-5-Hydroxymethyl-4-Pyridyl)Methyl-4-Methylthiazoline-2-Thiones
  作者:Ito,Isoo; Et Al
  参考文献:Yakugaku Zasshi 日期:1975 卷标:95(8) 页码:944-8]
  
  123-22-8 + 345937-03-3 = 85-87-0
  反应条件:1.1 Reagents: Hydrogen Bromide Catalysts: (+/-)-Propylene Oxide2.1 -
  标题:Aminodiphosphonic Acids And Diaminodiphosphonic Acids - Synthesis And Transamination Behavior
  作者:Issleib,K.; Et Al
  参考文献:Phosphorus And Sulfur And The Related Elements 日期:1983 卷标:14(2) 页码:171-8]
  
  1606-75-3 + 91-00-9 = 85-87-0
  反应条件:1.1 -2.1 Reagents: Hydrogen Bromide Catalysts: (+/-)-Propylene Oxide3.1 -
  标题:Aminodiphosphonic Acids And Diaminodiphosphonic Acids - Synthesis And Transamination Behavior
  作者:Issleib,K.; Et Al
  参考文献:Phosphorus And Sulfur And The Related Elements 日期:1983 卷标:14(2) 页码:171-8]
  
  54-12-6 + 65-22-5 = 85-87-0
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 5 D,Ph 6.8,15 °C
  标题:Kinetics And Mechanism Of The Condensation Of Pyridoxal With Amino Acids
  作者:Pishchugin,F. V.; Et Al
  参考文献:Russian Journal Of General Chemistry 日期:2005 卷标:75(9) 页码:1465-1468

海关参考信息

• 2905110000-甲醇
  2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管